Evidence map›Paper›PMID 23559480›Full record

ArticleThe Journal of general virology2013

RAGE inhibits human respiratory syncytial virus syncytium formation by interfering with F-protein function.

Jane Tian, Kelly Huang, Subramaniam Krishnan, Catherine Svabek, Daniel C Rowe, Yambasu Brewah, Miguel Sanjuan, Andriani C Patera, Roland Kolbeck, Ronald Herbst and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of general virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Exploring Therapeutic Targets From Spreading Patterns Against Respiratory Syncytial Virus.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
  6. Respiratory Syncytial Virus Fusion Activity Syncytia Assay.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Molecular Characteristics of RAGE and Advances in Small-Molecule Inhibitors.International journal of molecular sciences · 2021
    Review
  13. Article
  14. Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jane TianResearch Department, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.
Kelly HuangResearch Department, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.
Subramaniam KrishnanResearch Department, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.
Catherine SvabekResearch Department, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.
Daniel C RoweResearch Department, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.
Yambasu BrewahResearch Department, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.
Miguel SanjuanResearch Department, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.
Andriani C PateraResearch Department, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.
Roland KolbeckResearch Department, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.
Ronald HerbstResearch Department, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.
Gary P SimsResearch Department, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infection. Infection is critically dependent on the RSV fusion (F) protein, which mediates fusion between the viral envelope and airway epithelial cells. The F protein is also expressed on infected cells and is responsible for fusion of infected cells with adjacent cells, resulting in the formation of multinucleate syncytia. The receptor for advanced glycation end products (RAGE) is a pattern-recognition receptor that is constitutively highly expressed by type I alveolar epithelial cells. Here, we report that RAGE protected HEK cells from RSV-induced cell death and reduced viral titres in vitro. RAGE appeared to interact directly with the F protein, but, rather than inhibiting RSV entry into host cells, virus replication and budding, membrane-expressed RAGE or soluble RAGE blocked F-protein-mediated syncytium formation and sloughing. These data indicate that RAGE may contribute to protecting the lower airways from RSV by inhibiting the formation of syncytia, viral spread, epithelial damage and airway obstruction.

Indexed as

Host-Pathogen InteractionsCells, CulturedEpithelial CellsGiant CellsHumansReceptor for Advanced Glycation End ProductsRespiratory Syncytial Virus, HumanViral Fusion ProteinsF protein, human respiratory syncytial virusReceptor for Advanced Glycation End ProductsViral Fusion Proteins

Identifiers

PMID23559480
PMCPMC3749528
OpenAlexW2109958803

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.