Trial reportInternational journal of colorectal disease2013
Sacral neuromodulation for fecal incontinence and "low anterior resection syndrome" following neoadjuvant therapy for rectal cancer.
Trial report in International journal of colorectal disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04063293 (The Effect of Platelet Rich Plasma Injection Into the Anal Sphincters on Fecal Incontinence and Quality of Life in Incontinent Patients Had Treated With Low Anterior Resection for Rectal Cancer), which is not on this map. Cited by 21 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Platelet Rich Plasma Injection Into the Anal Sphincters on Fecal Incontinence and Quality of Life in Incontinent Patients Had Treated With Low Anterior Resection for Rectal Cancer
Who cites it
21 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Systematic review of the management options available for low anterior resection syndrome (LARS).Techniques in coloproctology · 2025Pooled it
- Sacral neuromodulation for low anterior resection syndrome: current status-a systematic review and meta-analysis.International journal of colorectal disease · 2023Pooled it
- Tools for fecal incontinence assessment: lessons for inflammatory bowel disease trials based on a systematic review.United European gastroenterology journal · 2020Pooled it
- The efficacy of sacral neuromodulation in the treatment of low anterior resection syndrome: a systematic review and meta-analysis.Techniques in coloproctology · 2020Pooled it
- Conversations for providers caring for patients with rectal cancer: Comparison of long-term patient-centered outcomes for patients with low rectal cancer facing ostomy or sphincter-sparing surgery.CA: a cancer journal for clinicians · 2016Pooled it
- [Anorectal functional disorders following organ-preserving treatment and resection of rectal cancer].Chirurgie (Heidelberg, Germany) · 2026Review
- Long-term outcomes of sacral neuromodulation for low anterior resection syndrome after rectal cancer surgery.Annals of coloproctology · 2024Article
- Sacral neuromodulation for the prevention of a permanent stoma in patients with severe defecation disorder following intersphincteric resection.Surgery today · 2021Article
- [Low anterior resection syndrome-Causes and treatment approaches].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2021Review
- Efficacy of biofeedback therapy for objective improvement of pelvic function in low anterior resection syndrome.Annals of surgical treatment and research · 2019Article
- Perioperative radiotherapy is an independent risk factor for major LARS: a cross-sectional observational study.International journal of colorectal disease · 2018Observational
- [Sacral nerve modulation in coloproctology].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2018Review
- Treatment possibilities for low anterior resection syndrome: a review of the literature.International journal of colorectal disease · 2018Review
- Effectiveness of sacral nerve stimulation in fecal incontinence after multimodal oncologic treatment for pelvic malignancies: a multicenter study with 2-year follow-up.Techniques in coloproctology · 2018Article
- Sacral neurostimulation for low anterior resection syndrome after radical resection for rectal cancer: evaluation of treatment with the LARS score.Techniques in coloproctology · 2017Article
- Systematic review of health state utility values for economic evaluation of colorectal cancer.Health economics review · 2016Review
- Survivorship care plans for people with colorectal cancer: do they reflect the research evidence?Current oncology (Toronto, Ont.) · 2016Article
- Adverse events of sacral neuromodulation for fecal incontinence reported to the federal drug administration.World journal of gastrointestinal pharmacology and therapeutics · 2016Article
- Low anterior resection syndrome: a survey of the members of the American Society of Colon and Rectal Surgeons (ASCRS), the Spanish Association of Surgeons (AEC), and the Spanish Society of Coloproctology (AECP).International journal of colorectal disease · 2016Article
- Sacral neuromodulation for fecal incontinence and constipation in adult patients with anorectal malformation--a feasibility study in patients with or without sacral dysgenesis.International journal of colorectal disease · 2014Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt was the aim of this prospective study to analyze both feasibility and effectiveness of sacral neuromodulation for fecal incontinence and "low anterior resection syndrome" following neoadjuvant therapy for rectal cancer.
methodsAll patients who underwent sacral neuromdulation following neoadjuvant therapy for rectal cancer (preoperative radiochemotherapy, oncologic rectal resection with total mesorectal excision) were prospectively enrolled in the study. Only patients with failure of conservative treatment and without any evidence of residual or recurrent tumor disease were candidates for sacral neuromdulation which was performed by a two-stage procedure (diagnostic percutaneous test stimulation followed by definite implant). In addition to feasibility, primary end points included success (reduction of incontinent episodes), continence and defecation status (assessed by Cleveland Clinic Incontinence Score and Altomare score), and quality of life (EQ-5D). Anal manometry was performed preoperative and at 12-month follow-up. Follow-up information was derived from clinical examination 3, 6, and 12 months postoperatively.
resultsNine patients (three females, six males) with a mean age of 61 years underwent sacral neuromodulation following neoadjuvant therapy for rectal cancer. Implantation rate was 100 %. No septic morbidity was observed. After a mean follow-up of 12 months, mean Cleveland Clinic Incontinence Score was reduced from 18.2 to 6.0 (p < 0.01). Incontinence episodes were significantly reduced from 7 to 0.5 (per day) and 20 to 8 (per week). Fecal urgency, fragmented defecation, and soiling were improved or resolved in two thirds. Altomare score was significantly reduced from 21.0 to 9.3 (p < 0.01). Anorectal manometry did not correlate with clinical success. Quality of life was significantly improved (EQ-5D generic: 0.42 vs. 0.74, EQ-5D-VAS score: 20 vs. 90, p < 0.01).
conclusionsPreliminary results of sacral neuromodulation in patients with fecal incontinence and symptoms of "low anterior resection syndrome" are promising and enrich the therapeutic modalities if conservative management has failed.
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