ReviewBiomedical microdevices2013
Microengineered tumor models: insights & opportunities from a physical sciences-oncology perspective.
Review in Biomedical microdevices, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Functional biomaterials for biomimetic 3D in vitro tumor microenvironment modeling.In vitro models · 2023Review
- Biomaterials for Mimicking and Modelling Tumor Microenvironment.Advances in experimental medicine and biology · 2022Review
- Microengineered perfusable 3D-bioprinted glioblastoma model for in vivo mimicry of tumor microenvironment.Science advances · 2021Article
- The mechanical and pharmacological regulation of glioblastoma cell migration in 3D matrices.Journal of cellular physiology · 2019Article
- A three-dimensional engineered heterogeneous tumor model for assessing cellular environment and response.Nature protocols · 2018Article
- Fibroblast-associated tumour microenvironment induces vascular structure-networked tumouroid.Scientific reports · 2018Article
- The arrival of commercial bioprinters - Towards 3D bioprinting revolution!International journal of bioprinting · 2018Review
- Cancer and the metastatic substrate.Ecancermedicalscience · 2016Review
- Gene Co-Expression Analysis Predicts Genetic Variants Associated with Drug Responsiveness in Lung Cancer.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2016Article
- 3D culture broadly regulates tumor cell hypoxia response and angiogenesis via pro-inflammatory pathways.Biomaterials · 2015Article
- Recapitulating the Tumor Ecosystem Along the Metastatic Cascade Using 3D Culture Models.Frontiers in oncology · 2015Review
- Three-dimensional in vitro tumor models for cancer research and drug evaluation.Biotechnology advances · 2014Review
- A three-dimensional in vitro model of tumor cell intravasation.Integrative biology : quantitative biosciences from nano to macro · 2014Article
- In vitro models of tumor vessels and matrix: engineering approaches to investigate transport limitations and drug delivery in cancer.Advanced drug delivery reviews · 2014Review
- TISSUE ENGINEERING PERFUSABLE CANCER MODELS.Current opinion in chemical engineering · 2014Article
- Interfacing polymeric scaffolds with primary pancreatic ductal adenocarcinoma cells to develop 3D cancer models.Biomatter · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Prevailing evidence has established the fundamental role of microenvironmental conditions in tumorigenesis. However, the ability to identify, interrupt, and translate the underlying cellular and molecular mechanisms into meaningful therapies remains limited, due in part to a lack of organotypic culture systems that accurately recapitulate tumor physiology. Integration of tissue engineering with microfabrication technologies has the potential to address this challenge and mimic tumor heterogeneity with pathological fidelity. Specifically, this approach allows recapitulating global changes of tissue-level phenomena, while also controlling microscale variability of various conditions including spatiotemporal presentation of soluble signals, biochemical and physical characteristics of the extracellular matrix, and cellular composition. Such platforms have continued to elucidate the role of the microenvironment in cancer pathogenesis and significantly improve drug discovery and screening, particularly for therapies that target tumor-enabling stromal components. This review discusses some of the landmark efforts in the field of micro-tumor engineering with a particular emphasis on deregulated tissue organization and mass transport phenomena in the tumor microenvironment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.