Trial reportEuropean journal of pediatrics2013
Comparison between daily supplementation doses of 200 versus 400 IU of vitamin D in infants.
Trial report in European journal of pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Relationship Between Vitamin D Intake and Serum 25-hydroxyvitamin D in Young Children: A Meta-Regression to Inform WHO/FAO Vitamin D Intake Recommendations.The Journal of nutrition · 2024Pooled it
- Vitamin D intakes and health outcomes in infants and preschool children: Summary of an evidence report.Annals of medicine · 2022Pooled it
- Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years of age.The Cochrane database of systematic reviews · 2020Pooled it
- Vitamin D fortification of growing up milk prevents decrease of serum 25-hydroxyvitamin D concentrations during winter: a clinical intervention study in Germany.European journal of pediatrics · 2013Trial
- Multilevel analysis of infant sunlight exposure practices among mothers in Mettu district Illubabor zone Oromia Ethiopia.Scientific reports · 2025Article
- Vitamin D prophylaxis in infancy.BMC pediatrics · 2021Review
- Nephrolithiasis during the first 6 months of life in exclusively breastfed infants.Pediatric nephrology (Berlin, Germany) · 2021Article
- An Assessment of Risk Factors for Insufficient Levels of Vitamin D during Early Infancy.Nutrients · 2021Article
- Assessment of Practice and Factors associated with Sunlight Exposure of Infants among Mothers in Debre Berhan Town, North Shewa Zone, Amhara Region, Ethiopia.Pediatric health, medicine and therapeutics · 2021Article
- Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians.Italian journal of pediatrics · 2018Review
- Do all infants need vitamin D supplementation?PloS one · 2018Article
- Shelf life after opening of prescription medicines and supplements with vitamin DEuropean journal of hospital pharmacy : science and practice · 2017Article
- Vitamin D in childhood and adolescence: an expert position statement.European journal of pediatrics · 2015Review
- Vitamin D deficiency in a tropical country--treatment and prevention in children.Indian journal of pediatrics · 2014Review
- The Approach to Tetanic Hypocalcemia Caused by Vitamin D Deficiency.Current health sciences journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The daily supplementation of vitamin D is mandatory for infants. However, there are still conflicting opinions about the exact daily dose. Thus, we aimed to evaluate a daily supplementation dose of 200 IU is sufficient and compared the supplementation doses of 200 and 400 IU per day. One hundred and sixty-nine infants were randomly assigned to two groups (group 1, 200 IU/day; group 2, 400 IU/day) and there were 75 infants in group 1 and 64 were in group 2 with a total number of 139. The median levels of 25-hydroxyvitamin D3 were significantly increased in group 2 at the age of 4 months (group 1, 39.60 mcg/L; group 2, 56.55 mcg/L; p < 0.0001). We clearly demonstrated that at the age of 4 months, none of the infants on the group 2 had a serum level of 25-hydroxyvitamin D3 less than 30 mcg/L. However, 21.3% of the infants in group 1 had a level below 30 mcg/L. Thus, in order to avoid vitamin D deficiency and rickets, we recommend supplementation dose of vitamin D at 400 IU/day as a safe and effective dose.
Indexed as
Identifiers
23559332What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.