ArticleStroke2013
Heritability estimates identify a substantial genetic contribution to risk and outcome of intracerebral hemorrhage.
Article in Stroke, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00930280 (Genetic and Environmental Risk Factors for Hemorrhagic Stroke), which is not on this map. Cited by 54 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic and Environmental Risk Factors for Hemorrhagic Stroke
Who cites it
54 citing papers in PubMed, 7 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Risk Factors for Intracerebral Hemorrhage: Genome-Wide Association Study and Mendelian Randomization Analyses.Stroke · 2024Pooled it
- Role of LDL-C level alteration in increased mortality risks in spontaneous intracerebral hemorrhage patients: Systematic review and meta-analysis.Frontiers in neurology · 2023Pooled it
- Genetic risk of Spontaneous intracerebral hemorrhage: Systematic review and future directions.Journal of the neurological sciences · 2019Pooled it
- Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/Ethnicity: A Meta-analysis.JAMA neurology · 2019Pooled it
- Pooled it
- Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for intracerebral hemorrhage.American journal of human genetics · 2014Pooled it
- Association between APOC1 polymorphism and Alzheimer's disease: a case-control study and meta-analysis.PloS one · 2014Pooled it
- Predicting symptomatic intracerebral hemorrhage versus lacunar disease in patients with longstanding hypertension.Stroke · 2014Trial
- Genetics of intracerebral hemorrhage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Influence of Ancestral and Geographic Factors on Intracerebral Hemorrhage Risks Among Africans and Americans.Stroke · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Identification of Genetic Loci Associated With Intracerebral Hemorrhage Using a Multitrait Analysis Approach.Neurology · 2024Article
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- Spontaneous Intracranial Hemorrhages in a Community of Asian Americans: Case Series and Literature Review.Cureus · 2024Article
- Genetic and Nongenetic Components of Stroke Family History: A Population Study of Adopted and Nonadopted Individuals.Journal of the American Heart Association · 2023Article
- Association between gut microbiome and intracerebral hemorrhage based on genome-wide association study data.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- Genetic Risk Score Improves Risk Stratification for Anticoagulation-Related Intracerebral Hemorrhage.Stroke · 2023Article
- Review
- Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association.Circulation · 2023Review
- Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage.International journal of molecular sciences · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
41 authors at 1 institution in 1 country.
Funding
Abstract
background and purposePrevious studies suggest that genetic variation plays a substantial role in occurrence and evolution of intracerebral hemorrhage (ICH). Genetic contribution to disease can be determined by calculating heritability using family-based data, but such an approach is impractical for ICH because of lack of large pedigree-based studies. However, a novel analytic tool based on genome-wide data allows heritability estimation from unrelated subjects. We sought to apply this method to provide heritability estimates for ICH risk, severity, and outcome.
methodsWe analyzed genome-wide genotype data for 791 ICH cases and 876 controls, and determined heritability as the proportion of variation in phenotype attributable to captured genetic variants. Contribution to heritability was separately estimated for the APOE (encoding apolipoprotein E) gene, an established genetic risk factor, and for the rest of the genome. Analyzed phenotypes included ICH risk, admission hematoma volume, and 90-day mortality.
resultsICH risk heritability was estimated at 29% (SE, 11%) for non-APOE loci and at 15% (SE, 10%) for APOE. Heritability for 90-day ICH mortality was 41% for non-APOE loci and 10% (SE, 9%) for APOE. Genetic influence on hematoma volume was also substantial: admission volume heritability was estimated at 60% (SE, 70%) for non-APOEloci and at 12% (SE, 4%) for APOE.
conclusionsGenetic variation plays a substantial role in ICH risk, outcome, and hematoma volume. Previously reported risk variants account for only a portion of inherited genetic influence on ICH pathophysiology, pointing to additional loci yet to be identified.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.