ArticleMolecular and cellular biology1990
Functional analysis of elements affecting expression of the beta-actin gene of carp.
Article in Molecular and cellular biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 92 citations in OpenAlex.
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- Cloning, characterization, and transcriptional activity of β-actin promoter of African catfish (Clarias gariepinus).Molecular biology reports · 2021Article
- Functional Analysis of the Promoter Region of Japanese Flounder (International journal of molecular sciences · 2018Article
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- Function and regulation domains of a newly isolated putative β-actin promoter from pacific white shrimp.PloS one · 2015Article
- Functional analysis of the promoter region of amphioxus β-actin gene: a useful tool for driving gene expression in vivo.Molecular biology reports · 2014Article
- A transgenic zebrafish model for monitoring glucocorticoid receptor activity.Genes, brain, and behavior · 2014Article
- Isolation of yellow catfish β-actin promoter and generation of transgenic yellow catfish expressing enhanced yellow fluorescent protein.Transgenic research · 2012Article
- Effective generation of transgenic reporter and gene trap lines of the medaka (Oryzias latipes) using the Ac/Ds transposon system.Transgenic research · 2012Article
- Functional ability of cytoskeletal β-actin regulator to drive constitutive and ubiquitous expression of a fluorescent reporter throughout the life cycle of transgenic marine medaka Oryzias dancena.Transgenic research · 2011Article
- Somatic mutagenesis with a Sleeping Beauty transposon system leads to solid tumor formation in zebrafish.PloS one · 2011Article
- Duration of expression and activity of Sleeping Beauty transposase in mouse liver following hydrodynamic DNA delivery.Molecular therapy : the journal of the American Society of Gene Therapy · 2010Article
- Isolation of Tanichthys albonubes beta actin gene and production of transgenic Tanichthys albonubes.Fish physiology and biochemistry · 2010Article
- The growth hormone-encoding gene isolated and characterized from Labeo rohita Hamilton is expressed in CHO cells under the control of constitutive promoters in 'autotransgene' constructs.Fish physiology and biochemistry · 2008Article
- Retention of the developmental pluripotency in medaka embryonic stem cells after gene transfer and long-term drug selection for gene targeting in fish.Transgenic research · 2004Article
- Position-independent expression of transgenes in zebrafish.Transgenic research · 1999Article
- High transgene activity in the yolk syncytial layer affects quantitative transient expression assays in zebrafish Danio rerio) embryos.Transgenic research · 1996Article
- Autogenous regulation of RNA translation and packaging by Rous sarcoma virus Pr76gag.Journal of virology · 1996Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Regulatory regions of the beta-actin gene of the common carp (Cyprinus carpio) have been examined by linking upstream, 5'-flanking sequences and regions of the first intron to a bacterial chloramphenicol acetyltransferase (CAT) reporter gene. By analysis of the mRNA products and encoded CAT activity, we have identified four putative regions that influence expression: (i) a negative regulatory region 2,300 to 1,100 base pairs (bp) ahead of the gene; (ii) a proximal promoter element, containing the highly conserved CCAAT, CC(A/T)6GG, and TATA boxes, that is within the first 204 bp upstream of the initiation site; (iii) a negative element of 426 bp in the 5' region of the first intron; and (iv) a positive 304-bp element near the end of the first intron that contains highly conserved sequences found in all characterized beta-actin genes. The positive intron element is not a classical enhancer; it is position and orientation dependent, as has been observed in other housekeeping genes in vertebrates. Depending on the elements joined together, CAT gene expression can be modulated more than 500-fold in transfected mouse cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.