ReviewPflugers Archiv : European journal of physiology2013
Sex differences in neuroadaptation to alcohol and withdrawal neurotoxicity.
Review in Pflugers Archiv : European journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed.
- Alcohol-Induced Amnesia and Personalized Drinking Feedback: Blackouts Predict Intervention Response.Behavior therapy · 2019Trial
- Spatial transcriptomics analysis uncovers ER stress in MANF-deficient Purkinje cells underlying alcohol-induced cerebellar neurodegeneration in mice.Acta neuropathologica communications · 2025Article
- Neuropeptide Y1 receptor expressing circuit from the central amygdala to lateral hypothalamus modulates binge-like ethanol consumption in a sex-dependent manner.Alcohol, clinical & experimental research · 2025Article
- A narrative review on alcohol use in women: insight into the telescoping hypothesis from a biopsychosocial perspective.The American journal of drug and alcohol abuse · 2025Review
- Analysis of theInternational journal of molecular sciences · 2024Article
- The role of brain serotonin signaling in excessive alcohol consumption and withdrawal: A call for more research in females.Neurobiology of stress · 2024Article
- Alcohol-drinking during later life by C57BL/6J mice induces sex- and age-dependent changes in hippocampal and prefrontal cortex expression of glutamate receptors and neuropathology markers.Addiction neuroscience · 2023Article
- The effects of binge drinking on attention in young adults.Frontiers in psychology · 2023Article
- Stress Drivers of Glucose Dynamics during Ozone Exposure Measured Using Radiotelemetry in Rats.Environmental health perspectives · 2022Article
- Effect of detoxification on N3 sleep correlates with brain functional but not structural changes in alcohol use disorder.Drug and alcohol dependence · 2022Article
- Chronic Intermittent Ethanol Administration during Adolescence Produces Sex Dependent Impairments in Behavioral Flexibility and Survivability.Brain sciences · 2022Article
- Sex as a Potential Moderator for Baclofen Response in the Treatment of Alcohol Dependence.Frontiers in global women's health · 2022Article
- Cholinergic and Neuroimmune Signaling Interact to Impact Adult Hippocampal Neurogenesis and Alcohol Pathology Across Development.Frontiers in pharmacology · 2022Review
- Severity of alcohol use disorder influences sex differences in sleep, mood, and brain functional connectivity impairments.Brain communications · 2022Article
- Research Needs for Inpatient Management of Severe Alcohol Withdrawal Syndrome: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2021Article
- Retrospective Hair Cortisol Concentrations from Pretreatment to Early Recovery in Alcohol Use Disorder.Alcohol and alcoholism (Oxford, Oxfordshire) · 2021Article
- Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years.Journal of neuroscience research · 2021Review
- Reactive, Adult Neurogenesis From Increased Neural Progenitor Cell Proliferation Following Alcohol Dependence in Female Rats.Frontiers in neuroscience · 2021Article
- Association between Alcohol Drinking Status and Depressive Symptoms in Korean Adults.Chonnam medical journal · 2021Article
- Sex and Age Effects on Neurobehavioral Toxicity Induced by Binge Alcohol.Brain plasticity (Amsterdam, Netherlands) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Recent work suggests that sex differences exist with regard to both the nature of neuroadaptation to alcohol during the development of dependence, and possibly, the neurodegenerative consequences of alcohol dependence. Volumetric studies in human samples show that females may demonstrate increased volumetric brain loss with equal or lesser dependence histories than males. Furthermore, animal studies demonstrate sex differences in glutamatergic, GABAergic, and adenosinergic receptor signaling and endocrine responses following prolonged alcohol exposure. These differences may influence the development of dependence, neuronal function, and viability, particularly during alcohol withdrawal. The present review discusses the current state of knowledge in this regard. It is concluded that there exists a clear need for a more extensive examination of potential sex differences in neurodegenerative consequences of alcohol dependence in men and women, particularly with regard to the role that alterations in amino acid signaling and hypothalamic-pituitary-adrenal axis function may play. Furthermore, we note the need for expanded examination of the unique role that alcohol withdrawal-associated neuronal activity may have in the development of dependence-associated neurotoxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.