ReviewVeterinary pathology2013
Principles for valid histopathologic scoring in research.
Review in Veterinary pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 415 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
415 citing papers in PubMed.
- Surveillance and biological characterization of H3 subtype avian influenza viruses in Eastern China.Virulence · 2026Article
- Comparative Therapeutic Effects of Lipid-Enriched and Ethanolic Garlic Extracts on DMBA-Induced Hepatic Carcinogenesis in Mice.Applied biochemistry and biotechnology · 2026Article
- Dietary watermelon (Citrullus lanatus) rind mitigates nickel- and copper-induced hepatic, metabolic, and nrf2/keap1 signaling disruptions in Nile tilapia (Oreochromis niloticus).Veterinary research communications · 2026Article
- Protective and therapeutic roles of Phoenix dactylifera L. Zaghloul cultivar leaves extract against ethanol-induced gastric ulcer in rats.Journal of molecular histology · 2026Article
- Plant-Mediated Silver Nanoparticle Formulations for Wound Healing: A Process-Property-Performance Perspective.Pharmaceutics · 2026Review
- Anti-Inflammatory Role of Exopolysaccharides in Osteoarthritis via Modulation of Redox and Inflammatory/Catabolic Signaling Networks.Applied biochemistry and biotechnology · 2026Article
- Dose-Dependent Protective Effects of Agmatine on Sublingual Gland Dysfunction and Pancreatic Damage in Experimental Diabetes: Evidence From Histological, Biochemical, and Immunohistochemical Analyses.Microscopy research and technique · 2026Article
- Dietary banana peels modulate waterborne oxyfluorfen-induced hepatotoxicity in Nile tilapia (Oreochromis niloticus) via regulation of redox homeostasis and ER stress signaling.Veterinary research communications · 2026Article
- Sublethal Acetamiprid Exposure Induces Ovarian Degeneration and HSP70/HSP90 Overexpression in Honey Bee Queens (Veterinary sciences · 2026Article
- Hesperidin dietary intervention mitigates ammonia stress-evoked biochemical and metabolic disruption and restores the tlr-5-nf-κβ/mapk gene expression in Oreochromis niloticus.Fish physiology and biochemistry · 2026Article
- Article
- Evaluation of Wound Healing in Wistar Rat Model via Curcumin-Functionalized Copper Nanoparticle Ointment.Applied biochemistry and biotechnology · 2026Article
- Epilepsy-induced heart damage and sudep risk: ion channelopathies, calcium homeostasis, and the therapeutic potential of resveratrol.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Astragaloside IV and rapamycin co-loaded bone marrow mesenchymal stem cell-derived exosome nanocarriers for targeted modulation of the PI3K/Akt/mTOR pathway in hepatocellular carcinoma.Nanomedicine (London, England) · 2026Article
- Mucin armoured diethylaminoethyl-dextran cloaked rebamipide based oral nanoformulation for the therapy of inflammatory bowel disease.Materials today. Bio · 2026Article
- Targeting oxidative stress-NLRP3-apoptotic-steroidogenic axis in doxorubicin-induced testicular toxicity: protective efficacy of ferulic acid niosomes.Biological research · 2026Article
- Effects of Clopidogrel on the Anticonvulsant Efficacy of Valproic Acid and Levetiracetam in a PTZ-Induced Seizure Model.International journal of molecular sciences · 2026Article
- Effects of dietary chitosan-flaxseed oil nanoemulsion on growth, economic performance, immunity, intestinal health, and cold-stress resistance in Nile tilapia (Oreochromis niloticus).Veterinary research communications · 2026Article
- Effects of ATP and Taxifolin on Atezolizumab-Induced Renal Injury: A Biochemical, Histopathological, and Immunofluorescence Evaluation.Life (Basel, Switzerland) · 2026Article
- Antihyperglycemic and Antioxidant Effects ofPharmaceutics · 2026Article
355 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Histopathologic scoring is a tool by which semiquantitative data can be obtained from tissues. Initially, a thorough understanding of the experimental design, study objectives, and methods is required for the pathologist to appropriately examine tissues and develop lesion scoring approaches. Many principles go into the development of a scoring system such as tissue examination, lesion identification, scoring definitions, and consistency in interpretation. Masking (aka "blinding") of the pathologist to experimental groups is often necessary to constrain bias, and multiple mechanisms are available. Development of a tissue scoring system requires appreciation of the attributes and limitations of the data (eg, nominal, ordinal, interval, and ratio data) to be evaluated. Incidence, ordinal, and rank methods of tissue scoring are demonstrated along with key principles for statistical analyses and reporting. Validation of a scoring system occurs through 2 principal measures: (1) validation of repeatability and (2) validation of tissue pathobiology. Understanding key principles of tissue scoring can help in the development and/or optimization of scoring systems so as to consistently yield meaningful and valid scoring data.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.