Trial reportJournal of assisted reproduction and genetics2013
Effect of the site of assisted hatching on vitrified-warmed blastocyst transfer cycles: a prospective randomized study.
Trial report in Journal of assisted reproduction and genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Assisted hatching on assisted conception (in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI)).The Cochrane database of systematic reviews · 2021Pooled it
- Revisiting embryo assisted hatching approaches: a systematic review of the current protocols.Journal of assisted reproduction and genetics · 2018Pooled it
- The development and phase 1 evaluation of a Decision Aid for elective egg freezing.BMC medical informatics and decision making · 2023Trial
- The Current Practice of Assisted Hatching for Embryos in Fertility Centres: a General Survey.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- From Zygote to Blastocyst: Application of Ultrashort Lasers in the Field of Assisted Reproduction and Developmental Biology.Diagnostics (Basel, Switzerland) · 2021Review
- Controlled hatching at the prescribed site using femtosecond laser for zona pellucida drilling at the early blastocyst stage.Journal of assisted reproduction and genetics · 2021Article
- Blastocyst hatching site is regularly distributed and does not influence foetal development in mice.Scientific reports · 2020Article
- The effect of the site of laser zona opening on the complete hatching of mouse blastocysts and their cell numbers.Clinical and experimental reproductive medicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess the effect of assisted hatching (AH) site on the clinical outcomes in vitrified-warmed blastocyst transfer cycles.
methodsA total of 160 women who underwent vitrified-warmed blastocyst transfer cycles were randomized to either the ICM group (AH performing at the site near the inner cell mess, ICM), or the TE group (AH performing at the site opposite to the ICM). AH with laser zona drilling was performed 20 or 30 min after thawing once the ICM can be detected. Clinical pregnancy rate, implantation rate, live birth rate and the occurrence rate of monozygotic twins (MZT) pregnancy after transfer of these two groups were compared.
resultsNo significant difference was found in the clinical pregnancy rate (63.8% vs. 67.5%), implantation rate (51.7% vs. 53.6%) and live birth rate (57.5% vs. 62.5%) between the ICM group and the TE group. The occurrence rate of MZT was comparable between the two groups (3.9% vs. 5.6%).
conclusionsThe site of assisted hatching has no influence on the implantation, pregnancy and live birth rate in human vitrified-warmed blastocyst transfer cycles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.