ArticleNeuroscience bulletin2013
Signaling mechanisms regulating myelination in the central nervous system.
Article in Neuroscience bulletin, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Red Fluorescent Labeling of Myelin by Membrane-Targeted tdTomato in Transgenic Mouse Lines.Glia · 2026Article
- Newly Identified Deficiencies in the Multiple Sclerosis Central Nervous System and Their Impact on the Remyelination Failure.Biomedicines · 2022Review
- Transcriptional regulators of the Golli/myelin basic protein locus integrate additive and stealth activities.PLoS genetics · 2020Article
- Article
- Cell Biology of Intracellular Adaptation ofMicrobiology spectrum · 2019Review
- Tau in Oligodendrocytes Takes Neurons in Sickness and in Health.International journal of molecular sciences · 2018Review
- The Protein Tyrosine Phosphatase Shp2 Regulates Oligodendrocyte Differentiation and Early Myelination and Contributes to Timely Remyelination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Regulation of Brain-Derived Neurotrophic Factor and Growth Factor Signaling Pathways by Tyrosine Phosphatase Shp2 in the Retina: A Brief Review.Frontiers in cellular neuroscience · 2018Review
- Limb Remote Ischemic Conditioning Promotes Myelination by Upregulating PTEN/Akt/mTOR Signaling Activities after Chronic Cerebral Hypoperfusion.Aging and disease · 2017Article
- Integrin-Linked Kinase (ILK) Deletion Disrupts Oligodendrocyte Development by Altering Cell Cycle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Article
- Neuronal Ndrg4 Is Essential for Nodes of Ranvier Organization in Zebrafish.PLoS genetics · 2016Article
- G protein-coupled receptor 37 is a negative regulator of oligodendrocyte differentiation and myelination.Nature communications · 2016Article
- Diversity Matters: A Revised Guide to Myelination.Trends in cell biology · 2016Review
- MR assessment of pediatric hydrocephalus: a road map.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Review
- Microglial phospholipase D4 deficiency influences myelination during brain development.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2016Article
- Serine/threonine-protein kinase PFTK1 modulates oligodendrocyte differentiation via PI3K/AKT pathway.Journal of molecular neuroscience : MN · 2015Article
- Disturbed macro-connectivity in schizophrenia linked to oligodendrocyte dysfunction: from structural findings to molecules.NPJ schizophrenia · 2015Review
- The effect of glia-glia interactions on oligodendrocyte precursor cell biology during development and in demyelinating diseases.Frontiers in cellular neuroscience · 2013Review
- Myelin in development and disease.Neuroscience bulletin · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The precise and coordinated production of myelin is essential for proper development and function of the nervous system. Diseases that disrupt myelin, including multiple sclerosis, cause significant functional disability. Current treatment aims to reduce the inflammatory component of the disease, thereby preventing damage resulting from demyelination. However, therapies are not yet available to improve natural repair processes after damage has already occurred. A thorough understanding of the signaling mechanisms that regulate myelin generation will improve our ability to enhance repair. in this review, we summarize the positive and negative regulators of myelination, focusing primarily on central nervous system myelination. Axon-derived signals, extracellular signals from both diffusible factors and the extracellular matrix, and intracellular signaling pathways within myelinating oligodendrocytes are discussed. Much is known about the positive regulators that drive myelination, while less is known about the negative regulators that shift active myelination to myelin maintenance at the appropriate time. Therefore, we also provide new data on potential negative regulators of CNS myelination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.