Evidence map›Paper›PMID 23558558›Full record

ArticleImmunogenetics2013

Cloning of a hamster anti-mouse CD79B antibody sequences and identification of a new hamster immunoglobulin lambda constant IGLC gene region.

Ryan Haggart, Jason Perera, Haochu Huang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunogenetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ryan HaggartDepartment of Medicine, Section of Rheumatology, Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60637, USA.
Jason Perera
Haochu Huang
University of Chicago · US

Funding

INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007090 · NIAID · UNIVERSITY OF CHICAGO · PI Peter Aidan Savage · 1985 to 2026
$11.7M
Thymic B cells and T cell selectionR01AI087645 · NIAID · UNIVERSITY OF CHICAGO · PI HUANG, HAOCHU · 2011 to 2015
$2.0M
NIAID NIH HHS 2T32AI007090NIAID NIH HHS R01 AI087645NIAID NIH HHS R01-AI087645NIAID NIH HHS T32 AI007090
6 · The paper itself

Abstract

Anti-CD79 antibodies have been effective at targeting B cell lymphoma cells and depleting B cells in animal models. In order to engineer recombinant antibodies with additional effector functions in mice, we cloned and sequenced the full-length cDNAs of the heavy and light chain of a hamster anti-mouse CD79B antibody. Although hamster antibodies represent a unique source of monoclonal antibodies against mouse, rat, and human antigens, sequence information of hamster immunoglobulins (IG) is sparse. Here, we report a new hamster (Cricetulus migratorius) IG lambda constant (IGLC) gene region that is most homologous to mouse IGLC2 and IGLC3.

Indexed as

Amino Acid SequenceAnimalsAntibodies, MonoclonalBase SequenceCD79 AntigensCloning, MolecularCricetinaeImmunoglobulin Constant RegionsImmunoglobulin lambda-ChainsMiceMolecular Sequence DataPhylogenyAntibodies, MonoclonalCD79 AntigensImmunoglobulin Constant RegionsImmunoglobulin lambda-Chains

Identifiers

PMID23558558
PMCPMC3686505
OpenAlexW1969353157

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.