SynthesisAmerican journal of epidemiology2013
Association of adiposity genetic variants with menarche timing in 92,105 women of European descent.
Synthesis in American journal of epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Identification of pleiotropic loci underlying hip bone mineral density and trunk lean mass.Journal of human genetics · 2021Pooled it
- Pooled it
- Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty.Human molecular genetics · 2014Pooled it
- Variation in the heritability of body mass index based on diverse twin studies: a systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2013Pooled it
- Adiposity and reproductive characteristics across the lifespan: a multi-ethnic population-based study in Northwest China.Reproductive health · 2026Article
- Shared Pathophysiological Mechanisms and Genetic Factors in Early Menarche and Polycystic Ovary Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Maternal Age at Menarche Genes Determines Fetal Growth Restriction Risk.International journal of molecular sciences · 2024Article
- Maternal Age at Menarche Gene Polymorphisms Are Associated with Offspring Birth Weight.Life (Basel, Switzerland) · 2023Article
- Mediation Effect of Obesity on the Association of Age at Menarche With Blood Pressure Among Women in Southwest China.Journal of the American Heart Association · 2023Article
- Growth and adrenarche: findings from the CATS observational study.Archives of disease in childhood · 2021Observational
- Polygenic interactions with adiposity rebound in the prediction of thelarche.Pediatric research · 2021Article
- Key steps for effective breast cancer prevention.Nature reviews. Cancer · 2020Review
- Childhood overweight and obesity and timing of puberty in boys and girls: cohort and sibling-matched analyses.International journal of epidemiology · 2020Article
- Candidate Genes for Age at Menarche Are Associated With Uterine Leiomyoma.Frontiers in genetics · 2020Article
- Maternal pre-pregnancy obesity and timing of puberty in sons and daughters: a population-based cohort study.International journal of epidemiology · 2019Article
- Interdisciplinary Work Is Essential for Research on Puberty: Complexity and Dynamism in Action.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2019Review
- Age at Menarche and Cardiometabolic Health: A Sibling Analysis in the Scottish Family Health Study.Journal of the American Heart Association · 2018Article
- Adiposity in relation to age at menarche and other reproductive factors among 300 000 Chinese women: findings from China Kadoorie Biobank study.International journal of epidemiology · 2017Article
- Causal Effect of Genetic Variants Associated With Body Mass Index on Multiple Sclerosis Susceptibility.American journal of epidemiology · 2017Article
- Age at menarche and risk of major cardiovascular diseases: Evidence of birth cohort effects from a prospective study of 300,000 Chinese women.International journal of cardiology · 2017Article
Corrections and comments
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75 authors.
Funding
Abstract
Obesity is of global health concern. There are well-described inverse relationships between female pubertal timing and obesity. Recent genome-wide association studies of age at menarche identified several obesity-related variants. Using data from the ReproGen Consortium, we employed meta-analytical techniques to estimate the associations of 95 a priori and recently identified obesity-related (body mass index (weight (kg)/height (m)(2)), waist circumference, and waist:hip ratio) single-nucleotide polymorphisms (SNPs) with age at menarche in 92,116 women of European descent from 38 studies (1970-2010), in order to estimate associations between genetic variants associated with central or overall adiposity and pubertal timing in girls. Investigators in each study performed a separate analysis of associations between the selected SNPs and age at menarche (ages 9-17 years) using linear regression models and adjusting for birth year, site (as appropriate), and population stratification. Heterogeneity of effect-measure estimates was investigated using meta-regression. Six novel associations of body mass index loci with age at menarche were identified, and 11 adiposity loci previously reported to be associated with age at menarche were confirmed, but none of the central adiposity variants individually showed significant associations. These findings suggest complex genetic relationships between menarche and overall obesity, and to a lesser extent central obesity, in normal processes of growth and development.
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