ArticleBiological psychiatry2013
Developmental disruption of gamma-aminobutyric acid function in the medial prefrontal cortex by noncontingent cocaine exposure during early adolescence.
Article in Biological psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 62 citations in OpenAlex.
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- Timing of Methamphetamine Exposure during Adolescence Differentially Influences Parvalbumin and Perineuronal Net Immunoreactivity in the Medial Prefrontal Cortex of Female, but Not Male, Rats.Developmental neuroscience · 2025Article
- Age-dependent effects of vaping on the prefrontal cortex, ventral tegmental area, and nucleus accumbens.Communications biology · 2024Article
- Late-adolescent onset of prefrontal endocannabinoid control of hippocampal and amygdalar inputs and its impact on trace-fear conditioning behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- mPFC DUSP1 mediates adolescent cocaine exposure-induced higher sensitivity to drug in adulthood.EMBO reports · 2023Article
- Maturation of Corticolimbic Functional Connectivity During Sensitive Periods of Brain Development.Current topics in behavioral neurosciences · 2022Article
- Developmental regulation of excitatory-inhibitory synaptic balance in the prefrontal cortex during adolescence.Seminars in cell & developmental biology · 2021Article
- Adolescent oxycodone exposure inhibits withdrawal-induced expression of genes associated with the dopamine transmission.Addiction biology · 2021Article
- Prefrontal α7nAChR Signaling Differentially Modulates Afferent Drive and Trace Fear Conditioning Behavior in Adolescent and Adult Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- GABAergic polygenic risk for cocaine use disorder is negatively correlated with precuneus activity during cognitive control in African American individuals.Addictive behaviors · 2021Article
- Single Cocaine Exposure Inhibits GABA Uptake via Dopamine D1-Like Receptors in Adolescent Mice Frontal Cortex.Neurotoxicity research · 2020Article
- Downregulation of parvalbumin expression in the prefrontal cortex during adolescence causes enduring prefrontal disinhibition in adulthood.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Genetic Architecture and Molecular Neuropathology of Human Cocaine Addiction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- MK-801 Exposure during Adolescence Elicits Enduring Disruption of Prefrontal E-I Balance and Its Control of Fear Extinction Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Stress, sensitive periods, and substance abuse.Neurobiology of stress · 2019Review
- High frequency stimulation-induced plasticity in the prelimbic cortex of rats emerges during adolescent development and is associated with an increase in dopamine receptor function.Neuropharmacology · 2018Article
- Age- and sex-dependent effects of methamphetamine on cognitive flexibility and 5-HTBehavioural brain research · 2018Article
- Effects of amphetamine exposure during adolescence on behavior and prelimbic cortex neuron activity in adulthood.Brain research · 2018Article
- MicroRNA Expression Profiling in the Prefrontal Cortex: Putative Mechanisms for the Cognitive Effects of Adolescent High Fat Feeding.Scientific reports · 2018Article
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Abstract
backgroundDrug experimentation during adolescence is associated with increased risk of drug addiction relative to any other age group. To further understand the neurobiology underlying such liability, we investigate how early adolescent cocaine experience impacts medial prefrontal cortex (mPFC) network function in adulthood.
methodsA noncontingent administration paradigm was used to assess the impact of early adolescent cocaine treatment (rats; postnatal days [PD] 35-40) on the overall inhibitory regulation of mPFC activity in adulthood (PD 65-75) by means of histochemical and in vivo electrophysiological measures combined with pharmacologic manipulations.
resultsCocaine exposure during early adolescence yields a distinctive hypermetabolic prefrontal cortex state that was not observed in adult-treated rats (PD 75-80). Local field potential recordings revealed that early adolescent cocaine exposure is associated with an attenuation of mPFC gamma-aminobutyric acid (GABA)ergic inhibition evoked by ventral hippocampal stimulation at beta and gamma frequencies that endures throughout adulthood. Such cocaine-induced mPFC disinhibition was not observed in adult-exposed animals. Furthermore, the normal developmental upregulation of parvalbumin immunoreactivity observed in the mPFC from PD 35 to PD 65 is lacking following early adolescent cocaine treatment.
conclusionsOur data indicate that repeated cocaine exposure during early adolescence can elicit a state of mPFC disinhibition resulting from a functional impairment of the local prefrontal GABAergic network that endures through adulthood. A lack of acquisition of prefrontal GABAergic function during adolescence could trigger long-term deficits in the mPFC that may increase the susceptibility for the onset of substance abuse and related psychiatric disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.