ArticleNeuroscience2013
Activation of both Group I and Group II metabotropic glutamatergic receptors suppress retinogeniculate transmission.
Article in Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Top-down modulation of the retinal code via histaminergic neurons of the hypothalamus.Science advances · 2024Article
- Article
- Retinal Inputs to the Thalamus Are Selectively Gated by Arousal.Current biology : CB · 2020Article
- Heterogeneous clinical and functional features of GRIN2D-related developmental and epileptic encephalopathy.Brain : a journal of neurology · 2019Article
- Voltage- and calcium-gated ion channels of neurons in the vertebrate retina.Progress in retinal and eye research · 2019Review
- Subset of Cortical Layer 6b Neurons Selectively Innervates Higher Order Thalamic Nuclei in Mice.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Synaptic properties of the lemniscal and paralemniscal pathways to the mouse somatosensory thalamus.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- An evolving view of retinogeniculate transmission.Visual neuroscience · 2017Review
- Thalamus plays a central role in ongoing cortical functioning.Nature neuroscience · 2016Review
- The Regulation of Corticofugal Fiber Targeting by Retinal Inputs.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- The Transformation of Adaptation Specificity to Whisker Identity from Brainstem to Thalamus.Frontiers in systems neuroscience · 2016Article
- Modulatory effects of activation of metabotropic glutamate receptors on GABAergic circuits in the mouse thalamus.Journal of neurophysiology · 2015Article
- Properties of the primary somatosensory cortex projection to the primary motor cortex in the mouse.Journal of neurophysiology · 2015Article
- Metabotropic glutamate receptor 5 shows different patterns of localization within the parallel visual pathways in macaque and squirrel monkeys.Eye and brain · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Relay cells of dorsal lateral geniculate nucleus (LGN) receive a Class 1 glutamatergic input from the retina and a Class 2 input from cortical layer 6. Among the properties of Class 2 synapses is the ability to activate metabotropic glutamate receptors (mGluRs), and mGluR activation is known to affect thalamocortical transmission via regulating retinogeniculate and thalamocortical synapses. Using brain slices, we studied the effects of Group I (dihydroxyphenylglycine) and Group II ((2S,2'R,3'R)-2-(2',3'-dicarboxycyclopropyl)glycine) mGluR agonists on retinogeniculate synapses. We showed that both agonists inhibit retinogeniculate excitatory postsynaptic currents (EPSCs) through presynaptic mechanisms, and their effects are additive and independent. We also found high-frequency stimulation of the layer 6 corticothalamic input produced a similar suppression of retinogeniculate EPSCs, suggesting layer 6 projection to LGN as a plausible source of activating these presynaptic mGluRs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.