Trial reportFertility and sterility2013
Functional neuroimaging of emotional processing in women with polycystic ovary syndrome: a case-control pilot study.
Trial report in Fertility and sterility, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Alterations in cognitive function among reproductive-age women with polyendocrine metabolic ovarian syndrome: A systematic review and meta-analysis.Journal of neuroendocrinology · 2026Pooled it
- Pooled it
- Insulin resistance is associated with depression risk in polycystic ovary syndrome.Fertility and sterility · 2018Trial
- Potential links between PCOS/PMOS and Alzheimer disease and related dementias.Journal of the Endocrine Society · 2026Review
- Changes in facial emotion processing and depression and anxiety symptoms with polycystic ovary syndrome treatment: a longitudinal, naturalistic study.Archives of women's mental health · 2026Article
- Resistant and Refractory Obesity: The Complexity of Anti-Obesity Therapy Failure.International journal of molecular sciences · 2026Review
- From metabolic network to brain loop: unraveling the neuro-metabolic correlates in PCOS-related depression.Frontiers in endocrinology · 2026Article
- Obesity and Insulin Resistance Alter Neural Processing of Unpleasant, but Not Pleasant, Visual Stimuli in Young Adults.Brain sciences · 2025Article
- Psychological symptoms and brain activity alterations in women with PCOS and their relation to the reduced quality of life: a narrative review.Journal of endocrinological investigation · 2024Review
- Drug repurposing for cancer therapy.Signal transduction and targeted therapy · 2024Review
- Food Cravings and Obesity in Women with Polycystic Ovary Syndrome: Pathophysiological and Therapeutic Considerations.Nutrients · 2024Review
- Polycystic Ovary Syndrome: Challenges and Possible Solutions.Journal of clinical medicine · 2023Article
- Polycystic Ovary Syndrome (PCOS) and Non-Suicidal Self-Injury (NSSI): A Community-Based Study.Healthcare (Basel, Switzerland) · 2022Article
- Associations Between Asthma and Polycystic Ovary Syndrome: Current Perspectives.Frontiers in endocrinology · 2022Review
- Changes in Mood, Anxiety, and Cognition with Polycystic Ovary Syndrome Treatment: A Longitudinal, Naturalistic Study.Neuropsychiatric disease and treatment · 2022Article
- Why are Women With Polycystic Ovary Syndrome at Increased Risk of Depression? Exploring the Etiological Maze.Cureus · 2021Review
- Changes in Resting-State Cerebral Activity in Women With Polycystic Ovary Syndrome: A Functional MR Imaging Study.Frontiers in endocrinology · 2020Article
- Increased cerebrospinal fluid levels of GABA, testosterone and estradiol in women with polycystic ovary syndrome.Human reproduction (Oxford, England) · 2017Observational
- Metabolic and hormone influences on emotion processing during menopause.Psychoneuroendocrinology · 2017Article
- Polycystic ovary syndrome and mental disorders: a systematic review and exploratory meta-analysis.Neuropsychiatric disease and treatment · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo evaluate emotional processing in women with insulin-resistant polycystic ovary syndrome (IR-PCOS) and its relationship to glucose regulation and the mu-opioid system.
designCase-control pilot.
settingTertiary referring medical center. PATIENT(S): Seven women with IR-PCOS and five non-insulin-resistant controls, aged 21-40 years, recruited from the general population. INTERVENTION(S): Sixteen weeks of metformin (1,500 mg/day) in women with IR-PCOS. MAIN OUTCOME MEASURE(S): Assessment of mood, metabolic function, and neuronal activation during an emotional task using functional magnetic resonance imaging (fMRI), and mu-opioid receptor availability using positive emission tomography (PET). RESULT(S): We found that insulin-resistant PCOS patients [1] had greater limbic activation during an emotion task than controls (n = 5); [2] trended toward decreased positive affect and increased trait anxiety; [3] after metformin treatment, had limbic activation that no longer differed from controls; and [4] had positive correlations between fMRI limbic activation during emotional processing and mu-opioid binding potential. CONCLUSION(S): Patients with IR-PCOS had greater regional activation during an emotion task than the controls, although this resolved with metformin therapy. Alterations in mu-opioid neurotransmission may underlie limbic system activity and mood disorders in IR-PCOS.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.