ArticleInvestigative ophthalmology & visual science2013
Comparative phospholipid profiles of control and glaucomatous human trabecular meshwork.
Article in Investigative ophthalmology & visual science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Exploring the Genetic Landscape of Childhood Glaucoma.Children (Basel, Switzerland) · 2024Review
- Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank.Nature communications · 2023Article
- An overview of lipidomics utilizing cadaver derived biological samples.Expert review of proteomics · 2021Article
- Membrane cholesterol regulates TRPV4 function, cytoskeletal expression, and the cellular response to tension.Journal of lipid research · 2021Article
- Association Between Serum Lipid Levels and Patients With Primary Angle-Closure Glaucoma in China: A Cross Sectional, Case-Control Study.Frontiers in medicine · 2021Article
- Alteration in Lysophospholipids and Converting Enzymes in Glaucomatous Optic Nerves.Investigative ophthalmology & visual science · 2020Article
- Differentiation of soluble aqueous humor metabolites in primary open angle glaucoma and controls.Experimental eye research · 2020Article
- Endogenous ocular lipids as potential modulators of intraocular pressure.Journal of cellular and molecular medicine · 2020Article
- Multi-Omics Approach for Studying Tears in Treatment-Naïve Glaucoma Patients.International journal of molecular sciences · 2019Article
- Optic Nerve Lipidomics Reveal Impaired Glucosylsphingosine Lipids Pathway in Glaucoma.Investigative ophthalmology & visual science · 2019Article
- The Role of Deimination in Regenerative Reprogramming of Neurons.Molecular neurobiology · 2019Article
- Crosslink between lipids and acute uveitis: a lipidomic analysis.International journal of ophthalmology · 2018Article
- Phospholipidomic Studies in Human Cornea From Climatic Droplet Keratopathy.Journal of cellular biochemistry · 2017Article
- Potential role of CYP1B1 in the development and treatment of metabolic diseases.Pharmacology & therapeutics · 2017Review
- Article
- Phospholipid makeup of the breast adipose tissue is impacted by obesity and mammary cancer in the mouse: Results of a pilot study.Biochimie · 2015Article
- Sphingolipids and ceramides of mouse aqueous humor: Comparative profiles from normotensive and hypertensive DBA/2J mice.Biochimie · 2014Article
- Article
- Human trabecular meshwork sphingolipid and ceramide profiles and potential latent fungal commensalism.Investigative ophthalmology & visual science · 2014Article
- Stool phospholipid signature is altered by diet and tumors.PloS one · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeWe compared phospholipid (phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, and phosphatidylinositol) profiles of control and glaucomatous trabecular meshwork (TM) derived from human donors.
methodsControl TM and most primary open angle glaucoma (POAG) TM were collected from cadaver donors. A select subset of POAG surgical TM samples also were collected for analyses. Lipid extraction was performed using a modification of the Bligh and Dyer method, protein concentrations were determined using the Bradford method, and for select samples confirmed with densitometry of PHAST gels. Lipids were identified and subjected to ratiometric quantification using a TSQ quantum Access Max triple quadrupole mass spectrometer with precursor ion scan (PIS) or neutral ion loss scan (NLS), using appropriate class specific lipid standards.
resultsThe comparative profiles of phosphatidylcholine, phosphatidylserine, phosphoethanolamine, and phosphatidylinositol between control and glaucomatous TM showed several species common between them. A number of unique lipids in all four phospholipid classes also were identified in control TM that were absent in glaucoma TM and vice versa.
conclusionsA number of phospholipids were found to be uniquely present in control but absent in glaucomatous TM and vice versa. Compared to a previous study of control and POAG blood, a number of these phospholipids are absent locally (TM), as well as systemically (in blood).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.