ArticleCancer science2013
Twist2 functions as a tumor suppressor in murine osteosarcoma cells.
Article in Cancer science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Regulation of the Epithelial to Mesenchymal Transition in Osteosarcoma.Biomolecules · 2023Review
- Biology and pathogenesis of human osteosarcoma.Oncology letters · 2020Review
- TWIST2: A new candidate tumor suppressor in prostate cancer.The Prostate · 2019Article
- Pancreatic (pro)enzymes treatment suppresses BXPC-3 pancreatic Cancer Stem Cell subpopulation and impairs tumour engrafting.Scientific reports · 2019Article
- The Kraken Wakes: induced EMT as a driver of tumour aggression and poor outcome.Clinical & experimental metastasis · 2018Review
- Basal p53 expression is indispensable for mesenchymal stem cell integrity.Cell death and differentiation · 2018Article
- Smoking and gender modify the effect ofOncotarget · 2017Article
- Knockdown of DDX46 Inhibits the Invasion and Tumorigenesis in Osteosarcoma Cells.Oncology research · 2017Article
- CXCL12/CXCR4 Axis Upregulates Twist to Induce EMT in Human Glioblastoma.Molecular neurobiology · 2016Article
- [Nicotine Induced Lung Cancer Cells Epithelial-mesenchymal Transition and Promote Its Vitro Invasion Potential].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2016Article
- Synergistic antiproliferative effect of imatinib and adriamycin in platelet-derived growth factor receptor-expressing osteosarcoma cells.Cancer science · 2015Article
- Regulation of p21 by TWIST2 contributes to its tumor-suppressor function in human acute myeloid leukemia.Oncogene · 2015Article
- Slug signaling is up-regulated by CCL21/CCR7 [corrected] to induce EMT in human chondrosarcoma.Medical oncology (Northwood, London, England) · 2015Article
- Article
- Notch signaling and EMT in non-small cell lung cancer: biological significance and therapeutic application.Journal of hematology & oncology · 2014Review
- EMT transcription factors: implication in osteosarcoma.Medical oncology (Northwood, London, England) · 2013Review
- Twist2 functions as a tumor suppressor in murine osteosarcoma cells.Cancer science · 2013Article
Corrections and comments
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Authors and funding
17 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The epithelial-mesenchymal transition (EMT) contributes to the malignant progression of cancer cells including acquisition of the ability to undergo metastasis. However, whereas EMT-related transcription factors (EMT-TF) are known to play an important role in the malignant progression of epithelial tumors, their role in mesenchymal tumors remains largely unknown. We show that expression of the gene for Twist2 is downregulated in human osteosarcoma and correlates inversely with tumorigenic potential in mouse osteosarcoma. Forced expression of Twist2 in highly tumorigenic murine osteosarcoma cells induced a slight inhibition of cell growth in vitro but markedly suppressed tumor formation in vivo. Conversely, knockdown of Twist2 in osteosarcoma cells with a low tumorigenic potential promoted tumor formation in vivo, suggesting that Twist2 functions as a tumor suppressor in osteosarcoma cells. Furthermore, Twist2 induced expression of fibulin-5, which has been reported as a tumor suppressor. Medium conditioned by mouse osteosarcoma cells overexpressing Twist2 inhibited expression of the MMP9 gene as well as invasion in mouse embryonic fibroblasts, and forced expression of Twist2 in osteosarcoma cells suppressed MMP9 gene expression in tumor tissue. Data from the present study suggest that Twist2 inhibits formation of a microenvironment conducive to tumor growth and thereby attenuates tumorigenesis in osteosarcoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.