ArticleThe Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association2014
Prevalence of orofacial clefts in Nigeria.
Article in The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- Variants in CALD1, ESRP1, and RBFOX1 are associated with orofacial cleft risk.PLoS genetics · 2025Pooled it
- Genetic disorders and congenital anomalies in Nigeria: a scoping review.Journal of community genetics · 2026Review
- Neonatal presentation of congenital adrenal hyperplasia accompanied by isolated cleft palate: case report.Oxford medical case reports · 2025Article
- Prevalence and Associated Factors of Malnutrition among Children Under Five Years with Clefts Attending a Hospital in Rwanda.Rwanda journal of medicine and health sciences · 2025Article
- The burden and care of orofacial cleft in Rwanda: a scoping review.BMC oral health · 2025Article
- Burden of orofacial clefts from 1990-2021 at global, regional, and national levels.Frontiers in pediatrics · 2025Article
- Challenges and coping mechanisms among caregivers of children with orofacial cleft in a Nigerian teaching hospital: photovoice approach.Frontiers in oral health · 2025Article
- Orofacial clefts in newborns in Brazil: a time series study, 2010-2021.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2025Article
- EMOTIONAL EXPERIENCES AND SOCIAL CHALLENGES OF OROFACIAL CLEFT IN RURAL SUB-SAHARAN AFRICA: A QUALITATIVE INTERPRETIVIST APPROACH.Annals of Ibadan postgraduate medicine · 2024Article
- Is telepractice effective in speech therapy for children with cleft lip and palate during the COVID-19 pandemic?Archives of craniofacial surgery · 2024Article
- EVALUATION OF OROFACIAL CLEFT COMMUNITY AWARENESS STRATEGIES USED IN A TERTIARY HOSPITAL IN NIGERIA.Annals of Ibadan postgraduate medicine · 2024Article
- Perceptions and beliefs of community gatekeepers about genomic risk information in African cleft research.BMC public health · 2024Article
- Orofacial cleft research in Nigeria: a bibliometric analysis.Sudanese journal of paediatrics · 2024Article
- Gastrulation-stage alcohol exposure induces similar rates of craniofacial malformations in male and female C57BL/6J mice.Birth defects research · 2024Article
- Demographic Profile of Patients with Cleft Lip and Palate Anomaly: 15-year Experience from a Tertiary Care Hospital and Teaching Institute in Wardha District of Maharashtra, India.International journal of clinical pediatric dentistry · 2023Article
- Descriptive epidemiology of external structural birth defects in Enugu State, Nigeria.Ghana medical journal · 2022Article
- Novel GRHL3 Variants in a South African Cohort With Cleft Lip and Palate.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2022Article
- Genome-wide Gene-by-Sex Interaction Studies Identify Novel Nonsyndromic Orofacial Clefts Risk Locus.Journal of dental research · 2022Article
- The genetic determinants of oral diseases in Africa: The gaps should be filled.Frontiers in oral health · 2022Review
- Pattern of Orofacial Clefts at A Tertiary Care Hospital in Ethiopia.Ethiopian journal of health sciences · 2021Article
Corrections and comments
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Authors and funding
18 authors at 3 institutions in 3 countries.
Funding
Abstract
Orofacial clefts are the most common malformations of the head and neck. In Africa, orofacial clefts are underascertained, with little or no surveillance system in most parts for clefts and other birth defects. A Nigerian craniofacial anomalies study, NigeriaCRAN, was established in 2006 to support cleft research specifically for epidemiological studies, treatment outcomes, and studies into etiology and prevention. We pooled data from seven of the largest Smile Train treatment centers in the six geopolitical zones in Nigeria. Data from September 2006 to June 2011 were analyzed and clefts compared between sides and genders using the Fisher exact test. A total of 2197 cases were identified during the study period, with an estimated prevalence rate of 0.5 per 1000. Of the total number of orofacial clefts, 54.4% occur in males and 45.6% in females. There was a significant difference (P = .0001) between unilateral left clefts and unilateral right clefts, and there was a significant difference (P = .0001) between bilateral clefts and clefts on either the left or right side. A significant gender difference (P = .03) was also observed for cleft palate, with more females than males. A total of 103 (4.7%) associated anomalies were identified. There were nine syndromic cleft cases, and 10.4% of the total number of individuals with clefts have an affected relative. The significant difference between unilateral clefts and the gender differences in the proportion of cleft palate only are consistent with the literature. The present study emphasizes the need for birth defects registries in developing countries in order to estimate the exact prevalence of birth defects including orofacial clefts.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.