Evidence map›Paper›PMID 23556125›Full record

ArticleTherapeutic advances in chronic disease2013

HIV stroke risk: evidence and implications.

Elyse J Singer, Miguel Valdes-Sueiras, Deborah L Commins, William Yong, Margrit Carlson

Open access · greenAbstract read
In one paragraph

Article in Therapeutic advances in chronic disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. New Directions in Infection-Associated Ischemic Stroke.Journal of clinical neurology (Seoul, Korea) · 2024
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. HIV Associated Risk Factors for Ischemic Stroke and Future Perspectives.International journal of molecular sciences · 2020
    Review
  14. Article
  15. Review
  16. Article
  17. Human immunodeficiency virus in institutionalized elderly people.Sao Paulo medical journal = Revista paulista de medicina · 2016
    Article
  18. The Importance of Thrombin in Cerebral Injury and Disease.International journal of molecular sciences · 2016
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Elyse J SingerNational Neurological AIDS Bank, Department of Neurology, David Geffen School of Medicine at UCLA, 11645 Wilshire Blvd, Suite 770, Los Angeles, CA 90025, USA.
Miguel Valdes-Sueiras
Deborah L Commins
William Yong
Margrit Carlson
University of California, Los Angeles · USUniversity of Southern California · US

Funding

UCLA SPOTRIAS CENTER APPLICATION RENEWAL-PROGRAM PROJECTP50NS044378 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VINTERS, HARRY V. · 2003 to 2012
$17.2M
West Coast AIDS and Cancer Specimen Resource (ACSR)U01CA066529 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCGRATH, MICHAEL SHANNON · 1994 to 2012
$16.1M
NATIONAL NEUROLOGICAL AIDS BANKU24MH100929 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SINGER, ELYSE J · 2013 to 2023
$12.5M
National Neurological AIDS BankU01MH083500 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SINGER, ELYSE J · 2008 to 2012
$7.2M
Neurobehavioral Deficits in HIV/HCV Infection Pre/Post Anti-HCV TherapyR01MH083553 · NIMH · BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE · PI HINKIN, CHARLES H · 2008 to 2012
$3.0M
Pathways to HIV-Associated Neurocognitive Disorders: A Systems Biology ApproachR01DA030913 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HORVATH, STEVE, LEVINE, ANDREW J · 2010 to 2014
$1.5M
NCI NIH HHS U01 CA066529NIDA NIH HHS R01 DA030913NIMH NIH HHS R01 MH083553NIMH NIH HHS U01 MH083500NIMH NIH HHS U24 MH100929NINDS NIH HHS P50 NS044378
6 · The paper itself

Abstract

An estimated 34 million men, women, and children are infected with human immunodeficiency virus type 1 (HIV-1), the virus that causes acquired immunodeficiency syndrome (AIDS). Current technology cannot eradicate HIV-1, and most patients with HIV-1-infection (HIV+) will require lifelong treatment with combined antiretroviral therapy (cART). Stroke was recognized as a complication of HIV-1 infection since the early days of the epidemic. Potential causes of stroke in HIV-1 include opportunistic infections, tumors, atherosclerosis, diabetes, hypertension, autoimmunity, coagulopathies, cardiovascular disease, and direct HIV-1 infection of the arterial wall. Ischemic stroke has emerged as a particularly significant neurological complication of HIV-1 and its treatment due to the aging of the HIV+ population, chronic HIV-1 infection, inflammation, and prolonged exposure to cART. New prevention and treatment strategies tailored to the needs of the HIV+ population are needed to address this issue.

Indexed as

atherosclerosiscerebrovascularhuman immunodeficiency virus type 1infectioninflammationstroke

Identifiers

PMID23556125
PMCPMC3610259
OpenAlexW2134552961

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.