ArticlePloS one2013
Diesel exhaust particles induce cysteine oxidation and s-glutathionylation in house dust mite induced murine asthma.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- NRF2-Dependent Placental Effects Vary by Sex and Dose following Gestational Exposure to Ultrafine Particles.Antioxidants (Basel, Switzerland) · 2022Article
- Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD.Antioxidants (Basel, Switzerland) · 2021Review
- Diesel Exhaust Particles and the Induction of Macrophage Activation and Dysfunction.Inflammation · 2018Review
- Effects of diesel exhaust particle exposure on a murine model of asthma due to soybean.PloS one · 2017Article
- Long-Term Effects of Diesel Exhaust Particles on Airway Inflammation and Remodeling in a Mouse Model.Allergy, asthma & immunology research · 2016Article
- Air pollution, physical activity, and markers of acute airway oxidative stress and inflammation in adolescents.Journal of the Georgia Public Health Association · 2016Article
- Article
- Outdoor air pollution and asthma.Lancet (London, England) · 2014Review
- Inhaled environmental allergens and toxicants as determinants of the asthma phenotype.Advances in experimental medicine and biology · 2014Review
- Overexpression of dimethylarginine dimethylaminohydrolase 1 attenuates airway inflammation in a mouse model of asthma.PloS one · 2014Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDiesel exhaust particle (DEP) exposure enhances allergic inflammation and has been linked to the incidence of asthma. Oxidative stress on the thiol molecules cysteine (Cys) and glutathione (GSH) can promote inflammatory host responses. The effect of DEP on the thiol oxidation/reduction (redox) state in the asthmatic lung is unknown.
objectiveTo determine if DEP exposure alters the Cys or GSH redox state in the asthmatic airway.
methodsBronchoalveolar lavage fluid was obtained from a house dust mite (HDM) induced murine asthma model exposed to DEP. GSH, glutathione disulfide (GSSG), Cys, cystine (CySS), and s-glutathionylated cysteine (CySSG) were determined by high pressure liquid chromatography.
resultsDEP co-administered with HDM, but not DEP or HDM alone, decreased total Cys, increased CySS, and increased CySSG without significantly altering GSH or GSSG.
conclusionsDEP exposure promotes oxidation and S-glutathionylation of cysteine amino acids in the asthmatic airway, suggesting a novel mechanism by which DEP may enhance allergic inflammatory responses.
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Registered trials
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