ArticlePloS one2013
Genome-wide detection of selective signature in Chinese Holstein.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Meta-Assembly of Selection Signatures in Cattle.PloS one · 2016Pooled it
- AlexandrusPS: A User-Friendly Pipeline for the Automated Detection of Orthologous Gene Clusters and Subsequent Positive Selection Analysis.Genome biology and evolution · 2023Article
- Diversity of Mitochondrial DNA Haplogroups and Their Association with Bovine Antral Follicle Count.Animals : an open access journal from MDPI · 2022Article
- Article
- Genome changes due to artificial selection in U.S. Holstein cattle.BMC genomics · 2019Article
- Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Genomic selection signatures in sheep from the Western Pyrenees.Genetics, selection, evolution : GSE · 2018Article
- Article
- Identification of selective sweeps reveals divergent selection between Chinese Holstein and Simmental cattle populations.Genetics, selection, evolution : GSE · 2016Article
- Breeding signature of combining ability improvement revealed by a genomic variation map from recurrent selection population in Brassica napus.Scientific reports · 2016Article
- Article
- Article
- Detection of selection signatures in dairy and beef cattle using high-density genomic information.Genetics, selection, evolution : GSE · 2015Article
- Relative extended haplotype homozygosity signals across breeds reveal dairy and beef specific signatures of selection.Genetics, selection, evolution : GSE · 2015Article
- Genomic signatures reveal new evidences for selection of important traits in domestic cattle.Molecular biology and evolution · 2015Article
- Article
- An interpretive review of selective sweep studies in Bos taurus cattle populations: identification of unique and shared selection signals across breeds.Frontiers in genetics · 2015Review
- Article
- Genome-wide detection of selective signatures in Simmental cattle.Journal of applied genetics · 2014Article
- Assessing signatures of selection through variation in linkage disequilibrium between taurine and indicine cattle.Genetics, selection, evolution : GSE · 2014Article
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6 authors.
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Abstract
Selective signatures in whole genome can help us understand the mechanisms of selection and target causal variants for breeding program. In present study, we performed Extended Haplotype Homozygosity (EHH) tests to identify significant core regions harboring such signals in Chinese Holstein, and then verified the biological significance of these identified regions based on commonly-used bioinformatics analyses. Results showed a total of 125 significant regions in entire genome containing some of important functional genes such as LEP, ABCG2, CSN1S1, CSN3 and TNF based on the Gene Ontology database. Some of these annotated genes involved in the core regions overlapped with those identified in our previous GWAS as well as those involved in a recently constructed candidate gene database for cattle, further indicating these genes under positive selection maybe underlie milk production traits and other important traits in Chinese Holstein. Furthermore, in the enrichment analyses for the second level GO terms and pathways, we observed some significant terms over represented in these identified regions as compared to the entire bovine genome. This indicates that some functional genes associated with milk production traits, as reflected by GO terms, could be clustered in core regions, which provided promising evidence for the exploitability of the core regions identified by EHH tests. Findings in our study could help detect functional candidate genes under positive selection for further genetic and breeding research in Chinese Holstein.
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