ArticlePloS one2013
Characterization of gastric and neuronal histaminergic populations using a transgenic mouse model.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Loss of the calorie restriction response protein DEPP1 worsens diet-induced obesity.Endocrinology · 2026Article
- Article
- Histamine as an Alert Signal in the Brain.Current topics in behavioral neurosciences · 2022Review
- Modern Imaging Technologies of Mast Cells for Biology and Medicine (Review).Sovremennye tekhnologii v meditsine · 2021Review
- Article
- Melanocortin regulation of histaminergic neurons via perifornical lateral hypothalamic melanocortin 4 receptors.Molecular metabolism · 2020Article
- Hypergastrinemia Expands Gastric ECL Cells Through CCK2RCellular and molecular gastroenterology and hepatology · 2020Article
- Reassessing the Role of Histaminergic Tuberomammillary Neurons in Arousal Control.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Distributions and relationships of chemically defined enteroendocrine cells in the rat gastric mucosa.Cell and tissue research · 2019Article
- Hypothalamic Tuberomammillary Nucleus Neurons: Electrophysiological Diversity and Essential Role in Arousal Stability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- A hypothesis of couplet molecules and couplet cells in gastric function and an association with Helicobacter pylori.BMC gastroenterology · 2016Article
- A Strong Stomach for Somatostatin.Endocrinology · 2015Article
- Neuroanatomical characterization of a growth hormone secretagogue receptor-green fluorescent protein reporter mouse.The Journal of comparative neurology · 2014Article
- Distinct cellular origins for serotonin-expressing and enterochromaffin-like cells in the gastric corpus.Gastroenterology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Histamine is a potent biogenic amine that mediates numerous physiological processes throughout the body, including digestion, sleep, and immunity. It is synthesized by gastric enterochromaffin-like cells, a specific set of hypothalamic neurons, as well as a subset of white blood cells, including mast cells. Much remains to be learned about these varied histamine-producing cell populations. Here, we report the validation of a transgenic mouse line in which Cre recombinase expression has been targeted to cells expressing histidine decarboxylase (HDC), which catalyzes the rate-limiting step in the synthesis of histamine. This was achieved by crossing the HDC-Cre mouse line with Rosa26-tdTomato reporter mice, thus resulting in the expression of the fluorescent Tomato (Tmt) signal in cells containing Cre recombinase activity. As expected, the Tmt signal co-localized with HDC-immunoreactivity within the gastric mucosa and gastric submucosa and also within the tuberomamillary nucleus of the brain. HDC expression within Tmt-positive gastric cells was further confirmed by quantitative PCR analysis of mRNA isolated from highly purified populations of Tmt-positive cells obtained by fluorescent activated cell sorting (FACS). HDC expression within these FACS-separated cells was found to coincide with other markers of both ECL cells and mast cells. Gastrin expression was co-localized with HDC expression in a subset of histaminergic gastric mucosal cells. We suggest that these transgenic mice will facilitate future studies aimed at investigating the function of histamine-producing cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.