ArticlePloS one2013
Re-evaluation of PD-1 expression by T cells as a marker for immune exhaustion during SIV infection.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 70 citations in OpenAlex.
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- PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation.The Journal of clinical investigation · 2018Trial
- Dynamic Shifts in Lymphocyte Subsets During the Menopausal Transition and Sexual Dimorphism in Immunosenescence.Immunity, inflammation and disease · 2026Article
- The impact of T cell exhaustion in hematopoietic stem cell transplantation.Stem cell research & therapy · 2026Review
- Protein-dependent CD4iScience · 2026Article
- Portrayed the development of activated T cell to exhausted T cell based on the ratio of CD28 to CTLA4.Cancer immunology, immunotherapy : CII · 2026Article
- Immunotherapy for locoregionally advanced nasopharyngeal carcinoma: a meta-analysis of randomized clinical trials.Therapeutic advances in medical oncology · 2026Article
- Selenopolysaccharide Isolated fromInternational journal of molecular sciences · 2024Article
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- Lipid metabolic reprogramming of hepatic CD4Microbiology spectrum · 2023Article
- Equine Arteritis Virus in Monocytic Cells Suppresses Differentiation and Function of Dendritic Cells.Viruses · 2023Article
- Review
- PD1 Expression in EGFRvIII-Directed CAR T Cell Infusion Product for Glioblastoma Is Associated with Clinical Response.Frontiers in immunology · 2022Article
- Germinal Center-Induced Immunity Is Correlated With Protection Against SARS-CoV-2 Reinfection But Not Lung Damage.The Journal of infectious diseases · 2021Article
- A Novel STK4 Mutation Impairs T Cell Immunity Through Dysregulation of Cytokine-Induced Adhesion and Chemotaxis Genes.Journal of clinical immunology · 2021Article
- The CD8Microbiology and molecular biology reviews : MMBR · 2021Review
- Functional Characteristics and Phenotypic Plasticity of CD57Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- MEK inhibition reprograms CD8Nature immunology · 2021Article
- Expression of immune checkpoints and T cell exhaustion markers in early and advanced stages of colorectal cancer.Cancer immunology, immunotherapy : CII · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
PD-1 expression is generally associated with exhaustion of T cells during chronic viral infections based on the finding that PD-1 expressing cells respond poorly to antigen activation and blockade of PD-1/PD-ligand interaction restores such antigen specific responses in vitro. We tested this hypothesis by examining PD-1 expression on virus-specific CD8 T cells and total T cells in vivo to determine whether PD-1 expression constitutes a reliable marker of immune exhaustion during SIV infection. The expression of PD-1 and Ki67 was monitored longitudinally on T cell subsets in peripheral blood, bone marrow, lymph node and rectal biopsy specimens from rhesus macaques prior to and post infection with pathogenic SIVmac239. During the course of infection, a progressive negative correlation was noted between PD-1 density and Ki67 expression in p11CM(+) CD8(+) T cells, as seen in other studies. However, for total and memory CD4 and CD8 T cells, a positive correlation was observed between PD-1 and Ki67 expression. Thus, while the levels of non-proliferating PD-1(+) p11CM(+) CD8 T cells were markedly elevated with progressing infection, such an increase was not seen on total T cells. In addition, total memory PD1(+) T cells exhibited higher levels of CCR5 than PD-1(-) T cells. Interestingly, few PD-1(+) CD8(+) T cells expressed CCR7 compared to PD-1(+) CD4 T cells and PD-1(-) T cells. In conclusion, overall PD1(+) T cells likely represent a particular differentiation stage or trafficking ability rather than exhaustion and in the context of chronic SIV infection, the level of PD-1 expression by T cells does not by itself serve as a reliable marker for immune exhaustion.
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Registered trials
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