Trial reportPloS one2013
Progressive adaptation in physical activity and neuromuscular performance during 520d confinement.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Trial
- Changes in real-world walking speed following 60-day bed-rest.NPJ microgravity · 2024Article
- Changes in the Mechanical Properties of Fast and Slow Skeletal Muscle after 7 and 21 Days of Restricted Activity in Rats.International journal of molecular sciences · 2023Article
- DNA methylation dynamics associated with long-term isolation of simulated space travel.iScience · 2022Article
- Confinement induces oxidative damage and synaptic dysfunction in mice.Frontiers in physiology · 2022Article
- Effects of home quarantine during COVID-19 lockdown on physical activity and dietary habits of adults in Saudi Arabia.Scientific reports · 2021Article
- Syndrome Differentiation of Chinese Medicine in Mars 500 Long-Term Closed Environment.Chinese journal of integrative medicine · 2020Article
- Social isolation during the COVID-19 pandemic can increase physical inactivity and the global burden of cardiovascular disease.American journal of physiology. Heart and circulatory physiology · 2020Article
- Multi-System Adaptation to Confinement During the 180-Day Controlled Ecological Life Support System (CELSS) Experiment.Frontiers in physiology · 2019Article
- Personalized Epigenome Remodeling Under Biochemical and Psychological Changes During Long-Term Isolation Environment.Frontiers in physiology · 2019Article
- Body composition and metabolic changes during a 520-day mission simulation to Mars.Journal of endocrinological investigation · 2018Article
- Sleep Quality Changes during Overwintering at the German Antarctic Stations Neumayer II and III: The Gender Factor.PloS one · 2016Article
- Need for Digital Biomarkers in Musculoskeletal Trials.Digital biomarkersReview
- Chair-Rising Power as Digital Biomarker: Validation against Jumping Power and Chair-Rising Time in Adults Aged 32-92 Years.Digital biomarkersArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To understand whether prolonged confinement results in reductions in physical activity and adaptation in the musculoskeletal system, six subjects were measured during 520 d isolation in the Mars500 study. We tested the hypothesis that physical activity reduces in prolonged confinement and that this would be associated with decrements of neuromuscular performance. Physical activity, as measured by average acceleration of the body's center of mass ("activity temperature") using the actibelt® device, decreased progressively over the course of isolation (p<0.00001). Concurrently, countermovement jump power and single-leg hop force decreased during isolation (p<0.001) whilst grip force did not change (p≥0.14). Similar to other models of inactivity, greater decrements of neuromuscular performance occurred in the lower-limb than in the upper-limb. Subject motivational state increased non-significantly (p = 0.20) during isolation, suggesting reductions in lower-limb neuromuscular performance were unrelated to motivation. Overall, we conclude that prolonged confinement is a form of physical inactivity and is associated with adaptation in the neuromuscular system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.