SynthesisPloS one2013
The Jarisch-Herxheimer reaction in leptospirosis: a systematic review.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 4 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Efficacy and safety outcomes reported in human leptospirosis studies to inform the development of a core outcome and core outcome measurement set: A systematic review.PLoS neglected tropical diseases · 2026Pooled it
- Corticosteroids for treatment of leptospirosis.The Cochrane database of systematic reviews · 2025Pooled it
- Tick borne relapsing fever - a systematic review and analysis of the literature.PLoS neglected tropical diseases · 2022Pooled it
- Cytokine response in human leptospirosis with different clinical outcomes: a systematic review.BMC infectious diseases · 2020Pooled it
- Jarisch-Herxheimer Reaction After Benzathine Penicillin G Treatment in Adults With Early Syphilis: Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2025Trial
- β-Lactam antibiotics trigger mouse TLR2/4- and human TLR2/5-dependent Jarisch-Herxheimer reaction in leptospirosis.bioRxiv : the preprint server for biology · 2026Article
- Distinct strategies of epithelial cell barrier disruption by Leptospira interrogans isolated from human patients in Okinawa, Japan.PLoS neglected tropical diseases · 2025Article
- Evolution of human leptospirosis in French Guiana, 2016-2022.PLoS neglected tropical diseases · 2025Article
- Anti-inflammatory cytokine profile and Jarisch-Herxheimer reaction in Leptospirosis patients: A prospective case-series study in New Caledonia.PLoS neglected tropical diseases · 2025Observational
- Distinguishing Jarisch-Herxheimer Reaction From Septic Shock in Leptospirosis Patients: A Case Study.The American journal of case reports · 2025Article
- A severe case of sepsis and pneumonia caused byOne health (Amsterdam, Netherlands) · 2025Article
- Leptospirosis.Nature reviews. Disease primers · 2025Review
- Review
- Jarisch-Herxheimer reaction following doxycycline therapy in an adolescent with cat scratch disease.IDCases · 2025Article
- Atypical clinical debut associated with Jarisch Herxheimer reaction in an asplenic patient with leptospirosis: case report and review.BMC infectious diseases · 2024Review
- A New Beginning to the Existing Medicines; Repurposing FDA-Approved Drugs for the Neglected Re-Emerging Disease Leptospirosis.ACS omega · 2024Article
- Neutralizing gut-derived lipopolysaccharide as a novel therapeutic strategy for severe leptospirosis.eLife · 2024Article
- A Patient with Severe Leptospirosis Treated with Cytokine Removal and High-Dose Corticosteroids.Infectious disease reports · 2022Article
- Gut microbiota involved in leptospiral infections.The ISME journal · 2022Article
- Next Generation Sequencing for Diagnosis of Leptospirosis Combined With Multiple Organ Failure: A Case Report and Literature Review.Frontiers in medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeptospirosis is an endemo-epidemic zoonotic disease associated with potentially fatal renal, cardiovascular or pulmonary failure. Recommended treatment includes antibiotics, which may induce a Jarisch-Herxheimer reaction (JHR). Since little information on the importance of this adverse event is available, we performed this review to quantify frequency and impact of JHR in leptospirosis management. METHODOLOGY/PRINCIPAL
findingsThis review systematically summarizes the literature on the JHR in leptospirosis. To approach the broader aspects of the subject, articles considering the treatment of leptospirosis, national leptospirosis guidelines and textbook and technical reports of the World Health Organisation were reviewed. Publications describing JHR in leptospirosis are very limited and consist mainly of single case reports and small case series. A single randomized control trial specifically assessed the JHR occurrence, but it has never been systematically investigated in large trials. Not all guidelines and not all literature on leptospirosis mention this reaction which can be fatal. CONCLUSIONS/SIGNIFICANCE: Although generally assumed to be a rare event, the true prevalence of JHR in leptospirosis is unknown and the awareness of this event is insufficient. All leptospirosis guidelines and local leptospirosis protocols should stress on systematic monitoring for clinical status early after antibiotic administration. Large well designed studies are required to precise the incidence and the impact of JHR as well as the severity and rates between various antibiotics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.