ArticlePloS one2013
Detection of mouse cough based on sound monitoring and respiratory airflow waveforms.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Mechanisms of bacterial host-to-host transmission.Microbiology and molecular biology reviews : MMBR · 2025Review
- No Pain, No Gain (and No Cough)? Discrete Brainstem Nuclei Coordinate Reflexive Cough and Pain Responses.American journal of respiratory cell and molecular biology · 2025Article
- A vagal-brainstem interoceptive circuit for cough-like defensive behaviors in mice.Nature neuroscience · 2024Article
- Neuroendocrine cells initiate protective upper airway reflexes.Science (New York, N.Y.) · 2024Article
- What Causes the Cough in Whooping Cough?mBio · 2022Article
- Article
- The Fim and FhaB adhesins play a crucial role in nasal cavity infection and Bordetella pertussis transmission in a novel mouse catarrhal infection model.PLoS pathogens · 2022Article
- Non-primate animal models for pertussis: back to the drawing board?Applied microbiology and biotechnology · 2022Review
- A descending pathway emanating from the periaqueductal gray mediates the development of cough-like hypersensitivity.iScience · 2022Article
- Hypersensitivity of Airway Reflexes Induced by Hydrogen Sulfide: Role of TRPA1 Receptors.International journal of molecular sciences · 2020Article
- Article
- Cough and expiration reflexes elicited by inhaled irritant gases are intensified in ovalbumin-sensitized mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Effects of ion channel noise on neural circuits: an application to the respiratory pattern generator to investigate breathing variability.Journal of neurophysiology · 2017Article
- Mechanical Stimulation by Postnasal Drip Evokes Cough.PloS one · 2015Article
- A One Health review of aerodigestive disease in dogs.Journal of veterinary internal medicineReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Detection for cough in mice has never yielded clearly audible sounds, so there is still a great deal of debates as to whether mice can cough in response to tussive stimuli. Here we introduce an approach for detection of mouse cough based on sound monitoring and airflow signals. 40 Female BALB/c mice were pretreated with normal saline, codeine, capasazepine or desensitized with capsaicin. Single mouse was put in a plethysmograph, exposed to aerosolized 100 µmol/L capsaicin for 3 min, followed by continuous observation for 3 min. Airflow signals of total 6 min were recorded and analyzed to detect coughs. Simultaneously, mouse cough sounds were sensed by a mini-microphone, monitored manually by an operator. When manual and automatic detection coincided, the cough was positively identified. Sound and sound waveforms were also recorded and filtered for further analysis. Body movements were observed by operator. Manual versus automated counts were compared. Seven types of airflow signals were identified by integrating manual and automated monitoring. Observation of mouse movements and analysis of sound waveforms alone did not produce meaningful data. Mouse cough numbers decreased significantly after all above drugs treatment. The Bland-Altman and consistency analysis between automatic and manual counts was 0.968 and 0.956. The study suggests that the mouse is able to present with cough, which could be detected by sound monitoring and respiratory airflow waveform changes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.