ArticlePloS one2013
Differential network analysis reveals genetic effects on catalepsy modules.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Modular PheWAS reveals the therapeutic heterogeneity landscape of Danghong injection on stable angina pectoris.Molecular biomedicine · 2026Article
- CorDiffViz: an R package for visualizing multi-omics differential correlation networks.BMC bioinformatics · 2021Article
- On the Use of Heterogeneous Stock Mice to Map Transcriptomes Associated With Excessive Ethanol Consumption.Frontiers in psychiatry · 2021Review
- Brain regional gene expression network analysis identifies unique interactions between chronic ethanol exposure and consumption.PloS one · 2020Article
- Co-Expression Network Analysis Identifies miRNA⁻mRNA Networks Potentially Regulating Milk Traits and Blood Metabolites.International journal of molecular sciences · 2018Article
- Gender-Specific Effects of Selection for Drinking in the Dark on the Network Roles of Coding and Noncoding RNAs.Alcoholism, clinical and experimental research · 2018Article
- Identifying the molecular targets ofRSC advances · 2018Article
- Network-Wide Screen Identifies Variation of Novel Precise On-Module Targets Using Conformational Modudaoism.CPT: pharmacometrics & systems pharmacology · 2018Article
- Network-Based Predictors of Progression in Head and Neck Squamous Cell Carcinoma.Frontiers in genetics · 2018Article
- Effects of selection for ethanol preference on gene expression in the nucleus accumbens of HS-CC mice.Genes, brain, and behavior · 2017Article
- Quantitative Identification of Compound-Dependent On-Modules and Differential Allosteric Modules From Homologous Ischemic Networks.CPT: pharmacometrics & systems pharmacology · 2016Article
- Transcriptome analysis of human cumulus cells reveals hypoxia as the main determinant of follicular senescence.Molecular human reproduction · 2016Article
- Cosplicing network analysis of mammalian brain RNA-Seq data utilizing WGCNA and Mantel correlations.Frontiers in genetics · 2015Article
- Dual-trait selection for ethanol consumption and withdrawal: genetic and transcriptional network effects.Alcoholism, clinical and experimental research · 2014Article
- The genetics of gene expression in complex mouse crosses as a tool to study the molecular underpinnings of behavior traits.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Review
- Network-based inference framework for identifying cancer genes from gene expression data.BioMed research international · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
We performed short-term bi-directional selective breeding for haloperidol-induced catalepsy, starting from three mouse populations of increasingly complex genetic structure: an F2 intercross, a heterogeneous stock (HS) formed by crossing four inbred strains (HS4) and a heterogeneous stock (HS-CC) formed from the inbred strain founders of the Collaborative Cross (CC). All three selections were successful, with large differences in haloperidol response emerging within three generations. Using a custom differential network analysis procedure, we found that gene coexpression patterns changed significantly; importantly, a number of these changes were concordant across genetic backgrounds. In contrast, absolute gene-expression changes were modest and not concordant across genetic backgrounds, in spite of the large and similar phenotypic differences. By inferring strain contributions from the parental lines, we are able to identify significant differences in allelic content between the selected lines concurrent with large changes in transcript connectivity. Importantly, this observation implies that genetic polymorphisms can affect transcript and module connectivity without large changes in absolute expression levels. We conclude that, in this case, selective breeding acts at the subnetwork level, with the same modules but not the same transcripts affected across the three selections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.