ArticlePloS one2013
Levels of lycopene β-cyclase 1 modulate carotenoid gene expression and accumulation in Daucus carota.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 105 citations in OpenAlex.
- DcLcyB1 and DcLcyB2, two lycopene β-cyclases with partial functional overlap modulate carotene profiles in carrot roots via distinct catalytic properties.Molecular horticulture · 2026Article
- Genome-Wide Identification of LCY Genes inPlants (Basel, Switzerland) · 2026Article
- Carotene hydroxylase DcCYP97A3 affects carotenoid metabolic flow and taproot color by influencing the conversion of α-carotene to lutein in carrot.Horticulture research · 2025Article
- Exploring the Potential of Carotenoids in Obesity Management: A Comprehensive Overview.Recent advances in food, nutrition & agriculture · 2025Review
- Integrative Targeted Metabolomics and Transcriptomics Reveal the Mechanism of Leaf Coloration inInternational journal of molecular sciences · 2024Article
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- Genomic Insights on the Carbon-Negative Workhorse: Systematical Comparative Genomic Analysis on 56Bioengineering (Basel, Switzerland) · 2023Article
- Gene structure and potential regulation of the lycopene cyclase genes inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2023Article
- Mechanisms for leaf color changes in Osmanthus fragrans 'Ziyan Gongzhu' using physiology, transcriptomics and metabolomics.BMC plant biology · 2023Article
- PutativePlants (Basel, Switzerland) · 2023Article
- Functional Characterization of Lycopene β- and ε-Cyclases from a Lutein-Enriched Green MicroalgaMarine drugs · 2023Article
- The Carrot Phytoene Synthase 2 (Plants (Basel, Switzerland) · 2023Article
- Article
- Carrot DcALFIN4 and DcALFIN7 Transcription Factors Boost Carotenoid Levels and Participate Differentially in Salt Stress Tolerance When Expressed inInternational journal of molecular sciences · 2022Article
- Development and carotenoid synthesis in dark-grown carrot taproots require PHYTOCHROME RAPIDLY REGULATED1.Plant physiology · 2022Article
- Functional characterization and comparison of lycopene epsilon-cyclase genes in Nicotiana tabacum.BMC plant biology · 2022Article
- Identification of QTLs for root color and carotenoid contents in Japanese orange carrot FScientific reports · 2022Article
- Comparative transcriptomics of wild and commercial Citrus during early ripening reveals how domestication shaped fruit gene expression.BMC plant biology · 2022Article
- Carotenoid metabolism: New insights and synthetic approaches.Frontiers in plant science · 2022Review
- Overexpression ofFrontiers in plant science · 2022Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant carotenoids are synthesized and accumulated in plastids through a highly regulated pathway. Lycopene β-cyclase (LCYB) is a key enzyme involved directly in the synthesis of α-carotene and β-carotene through the cyclization of lycopene. Carotenoids are produced in both carrot (Daucus carota) leaves and reserve roots, and high amounts of α-carotene and β-carotene accumulate in the latter. In some plant models, the presence of different isoforms of carotenogenic genes is associated with an organ-specific function. D. carota harbors two Lcyb genes, of which DcLcyb1 is expressed in leaves and storage roots during carrot development, correlating with an increase in carotenoid levels. In this work, we show that DcLCYB1 is localized in the plastid and that it is a functional enzyme, as demonstrated by heterologous complementation in Escherichia coli and over expression and post transcriptional gene silencing in carrot. Transgenic plants with higher or reduced levels of DcLcyb1 had incremented or reduced levels of chlorophyll, total carotenoids and β-carotene in leaves and in the storage roots, respectively. In addition, changes in the expression of DcLcyb1 are accompanied by a modulation in the expression of key endogenous carotenogenic genes. Our results indicate that DcLcyb1 does not possess an organ specific function and modulate carotenoid gene expression and accumulation in carrot leaves and storage roots.
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