ArticlePloS one2013
Morphine induces albuminuria by compromising podocyte integrity.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Endurance training mitigates morphine-induced renal dysfunction in young and aged rats: involvement of oxidative stress, SIRT1, Klotho and TFAM.Biogerontology · 2026Article
- Liver and Kidney Tissues Under Opioid Exposure: Rewriting and Old Story Through Proteomics and MALDI-MSI.Journal of proteome research · 2026Article
- Protective effect of linalool against morphine-induced renal injury: Modulation of oxidative stress and PI3K/AKT/L-FABP signaling pathway.Iranian journal of basic medical sciences · 2026Article
- Filtering the Signal: Kappa Opioid Receptors in the Kidney.Function (Oxford, England) · 2025Article
- Renal Implications of Kappa Opioid Receptor Signaling in Sprague-Dawley Rats.Function (Oxford, England) · 2025Article
- Sex and dose differences in morphine administration on renal function, inflammatory and apoptotic markers in male and female Wistar rats.Current research in physiology · 2025Article
- Opioids and the kidney: two sides of the same coin.Frontiers in pharmacology · 2024Review
- Effects of toxicants on endoplasmic reticulum stress and hepatic cell fate determination.Toxicological research · 2023Review
- Nicotine exacerbates diabetic nephropathy through upregulation of Grem1 expression.Molecular medicine (Cambridge, Mass.) · 2023Article
- Opioids and Acute Kidney Injury.Seminars in nephrology · 2021Review
- Role of opioid signaling in kidney damage during the development of salt-induced hypertension.Life science alliance · 2020Article
- EDA2R mediates podocyte injury in high glucose milieu.Biochimie · 2020Article
- Opioids Preconditioning Upon Renal Function and Ischemia-Reperfusion Injury: A Narrative Review.Medicina (Kaunas, Lithuania) · 2019Review
- The meaning of confounding adjustment in the presence of multiple versions of treatment: an application to organ transplantation.European journal of epidemiology · 2019Article
- APOL1 risk variants cause podocytes injury through enhancing endoplasmic reticulum stress.Bioscience reports · 2018Article
- Hedgehog pathway plays a vital role in HIV-induced epithelial-mesenchymal transition of podocyte.Experimental cell research · 2017Article
- Diabetes-Induced Reactive Oxygen Species: Mechanism of Their Generation and Role in Renal Injury.Journal of diabetes research · 2017Review
- Renoprotective effect of curcumin against the combined oxidative stress of diabetes and nicotine in rats.Molecular medicine reports · 2016Article
- Article
- Secondary Focal Segmental Glomerulosclerosis: From Podocyte Injury to Glomerulosclerosis.BioMed research international · 2016Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
Morphine has been reported to accelerate the progression of chronic kidney disease. However, whether morphine affects slit diaphragm (SD), the major constituent of glomerular filtration barrier, is still unclear. In the present study, we examined the effect of morphine on glomerular filtration barrier in general and podocyte integrity in particular. Mice were administered either normal saline or morphine for 72 h, then urine samples were collected and kidneys were subsequently isolated for immunohistochemical studies and Western blot. For in vitro studies, human podocytes were treated with morphine and then probed for the molecular markers of slit diaphragm. Morphine-receiving mice displayed a significant increase in albuminuria and showed effacement of podocyte foot processes. In both in vivo and in vitro studies, the expression of synaptopodin, a molecular marker for podocyte integrity, and the slit diaphragm constituting molecules (SDCM), such as nephrin, podocin, and CD2-associated protein (CD2AP), were decreased in morphine-treated podocytes. In vitro studies indicated that morphine modulated podocyte expression of SDCM through opiate mu (MOR) and kappa (KOR) receptors. Since morphine also enhanced podocyte oxidative stress, the latter seems to contribute to decreased SDCM expression. In addition, AKT, p38, and JNK pathways were involved in morphine-induced down regulation of SDCM in human podocytes. These findings demonstrate that morphine has the potential to alter the glomerular filtration barrier by compromising the integrity of podocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.