ReviewDeutsches Arzteblatt international2013
Human papilloma virus infection in head and neck cancer.
Review in Deutsches Arzteblatt international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Prior Tonsillectomy and the Risk of Breast Cancer in Females: A Systematic Review and Meta-analysis.Frontiers in oncology · 2022Pooled it
- A systematic review of the HPV-attributable fraction of oropharyngeal squamous cell carcinomas in Germany.Cancer medicine · 2019Pooled it
- Review
- Quality of life and health-related utility after trans-oral surgery for head and neck cancers.Health and quality of life outcomes · 2021Article
- Characteristics of carcinogenic HPV genotypes in North China Plain and the association with cervical lesions.Medicine · 2019Article
- HPV and Oropharyngeal Cancer in the Eighth Edition of the TNM Classification: Pitfalls in Practice.Translational oncology · 2019Article
- The nonavalent vaccine: a review of high-risk HPVs and a plea to the CDC.American journal of stem cells · 2019Review
- Awareness of head and neck cancer - a multicentre survey among young respondents in Poland.International dental journal · 2018Article
- Evaluation and validation of HPV real-time PCR assay for the detection of HPV DNA in oral cytobrush and FFPE samples.Scientific reports · 2018Article
- Human papillomavirus and gastrointestinal cancer: A review.World journal of gastroenterology · 2016Review
- Review
- Article
- Salivary and serum IL-10, TNF-α, TGF-β, VEGF levels in oropharyngeal squamous cell carcinoma and correlation with HPV and EBV infections.Infectious agents and cancer · 2016Article
- Review
- Combined P16 and human papillomavirus testing predicts head and neck cancer survival.International journal of cancer · 2014Article
- Surgically treated oropharyngeal cancer: risk factors and tumor characteristics.Journal of cancer research and clinical oncology · 2014Article
- Predictive value of epigenetic alterations in head and neck squamous cell carcinoma.Molecular & cellular oncologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe causal link between cervical cancer and human papilloma virus (HPV) is well known. It is now becoming clear that some types of squamous-cell carcinoma of the head and neck, particularly oropharyngeal carcinoma (OPC), are also linked to HPV infection. The development of vaccines against certain HPV genotypes has changed the management strategy for HPV-associated diseases of the uterine cervix. An analogous approach is now being considered for the prevention of HPV-associated diseases of the head and neck.
methodWe review pertinent articles retrieved by a selective search of the literature for phase II and III trials providing evidence about a possible effect of HPV status on the survival rates of patients with OPC. Seven trials fulfilled our search criteria: four phase III trials with retrospective HPV analysis and three phase II trials with retrospective and prospective HPV analysis.
resultsPatients with HPV-positive OPC survive significantly longer than those with HPV-negative OPC. Tobacco smoking has been identified as a negative prognostic factor in patients with either HPV-negative or HPV-positive disease.
conclusionThe established treatment strategy for OPC in patients with and without the traditional risk factors (tobacco and alcohol consumption) is now being reconsidered in the light of what we have learned about the role of HPV infection. Ongoing and projected clinical trials with risk-factor stratification may soon lead to changes in treatment. Further study is needed to answer the question whether HPV infection in the head and neck region is carcinogenic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.