ArticlePLoS genetics2013
A feed-forward loop coupling extracellular BMP transport and morphogenesis in Drosophila wing.
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Review
- Review
- Engineered kinases as a tool for phosphorylation of selected targets in vivo.The Journal of cell biology · 2022Article
- Coupling between dynamic 3D tissue architecture and BMP morphogen signaling duringProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Quantitative Morphological Variation in the DevelopingG3 (Bethesda, Md.) · 2018Article
- The integrated stress response regulates BMP signalling through effects on translation.BMC biology · 2018Article
- Scribbled Optimizes BMP Signaling through Its Receptor Internalization to the Rab5 Endosome and Promote Robust Epithelial Morphogenesis.PLoS genetics · 2016Article
- lolal Is an Evolutionarily New Epigenetic Regulator of dpp Transcription during Dorsal-Ventral Axis Formation.Molecular biology and evolution · 2016Article
- Article
- Article
- Making quantitative morphological variation from basic developmental processes: Where are we? The case of the Drosophila wing.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Review
- Insights into the molecular mechanisms underlying diversified wing venation among insects.Proceedings. Biological sciences · 2014Article
- Coordination of wing and whole-body development at developmental milestones ensures robustness against environmental and physiological perturbations.PLoS genetics · 2014Article
- Construction and analysis of microRNA-transcription factor regulation network in Arabidopsis.IET systems biology · 2014Article
- Studies of morphogens: keep calm and carry on.Development (Cambridge, England) · 2013Article
- New insights into extracellular and post-translational regulation of TGF-β family signalling pathways.Journal of biochemistry · 2013Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A variety of extracellular factors regulate morphogenesis during development. However, coordination between extracellular signaling and dynamic morphogenesis is largely unexplored. We address the fundamental question by studying posterior crossvein (PCV) development in Drosophila as a model, in which long-range BMP transport from the longitudinal veins plays a critical role during the pupal stages. Here, we show that RhoGAP Crossveinless-C (Cv-C) is induced at the PCV primordial cells by BMP signaling and mediates PCV morphogenesis cell-autonomously by inactivating members of the Rho-type small GTPases. Intriguingly, we find that Cv-C is also required non-cell-autonomously for BMP transport into the PCV region, while a long-range BMP transport is guided toward ectopic wing vein regions by loss of the Rho-type small GTPases. We present evidence that low level of ß-integrin accumulation at the basal side of PCV epithelial cells regulated by Cv-C provides an optimal extracellular environment for guiding BMP transport. These data suggest that BMP transport and PCV morphogenesis are tightly coupled. Our study reveals a feed-forward mechanism that coordinates the spatial distribution of extracellular instructive cues and morphogenesis. The coupling mechanism may be widely utilized to achieve precise morphogenesis during development and homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.