ArticlePLoS genetics2013
Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions.
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mining for novel candidate clock genes in the circadian regulatory network.BMC systems biology · 2015Pooled it
- Stable clocks, rewired rhythms: circadian remodeling in skeletal muscle during aging, cachexia, and type 2 diabetes.Life metabolism · 2026Review
- BHLHE41, a transcriptional repressor involved in physiological processes and tumor development.Cellular oncology (Dordrecht, Netherlands) · 2025Review
- HIF‑1 and macrophage activation signalling pathways are potential biomarkers of invasive aspergillosis.Experimental and therapeutic medicine · 2024Article
- Conformational changes in the negative arm of the circadian clock correlate with dynamic interactomes involved in post-transcriptional regulation.Cell reports · 2023Article
- Inferring cell cycle phases from a partially temporal network of protein interactions.Cell reports methods · 2023Article
- Gene networks under circadian control exhibit diurnal organization in primate organs.Communications biology · 2022Article
- PER2: a potential molecular marker for hematological malignancies.Molecular biology reports · 2021Review
- Circadian Interactomics: How Research Into Protein-Protein Interactions Beyond the Core Clock Has Influenced the Model of Circadian Timekeeping.Journal of biological rhythms · 2021Review
- Phosphorylation of GAPVD1 Is Regulated by the PER Complex and Linked to GAPVD1 Degradation.International journal of molecular sciences · 2021Article
- Transcriptional Control of Circadian Rhythms and Metabolism: A Matter of Time and Space.Endocrine reviews · 2020Review
- Systems Level Understanding of Circadian Integration with Cell Physiology.Journal of molecular biology · 2020Review
- The NRON complex controls circadian clock function through regulated PER and CRY nuclear translocation.Scientific reports · 2019Article
- Representing dynamic biological networks with multi-scale probabilistic models.Communications biology · 2019Article
- Circadian Mechanisms in Alcohol Use Disorder and Tissue Injury.Alcoholism, clinical and experimental research · 2018Review
- The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy.Cell systems · 2018Article
- Functional characterization of the circadian clock in the Antarctic krill, Euphausia superba.Scientific reports · 2017Article
- Cullin E3 Ligase Activity Is Required for Myoblast Differentiation.Journal of molecular biology · 2017Article
- Feedback Loops of the Mammalian Circadian Clock Constitute Repressilator.PLoS computational biology · 2016Article
- Histone monoubiquitination by Clock-Bmal1 complex marks Per1 and Per2 genes for circadian feedback.Nature structural & molecular biology · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Essentially all biological processes depend on protein-protein interactions (PPIs). Timing of such interactions is crucial for regulatory function. Although circadian (~24-hour) clocks constitute fundamental cellular timing mechanisms regulating important physiological processes, PPI dynamics on this timescale are largely unknown. Here, we identified 109 novel PPIs among circadian clock proteins via a yeast-two-hybrid approach. Among them, the interaction of protein phosphatase 1 and CLOCK/BMAL1 was found to result in BMAL1 destabilization. We constructed a dynamic circadian PPI network predicting the PPI timing using circadian expression data. Systematic circadian phenotyping (RNAi and overexpression) suggests a crucial role for components involved in dynamic interactions. Systems analysis of a global dynamic network in liver revealed that interacting proteins are expressed at similar times likely to restrict regulatory interactions to specific phases. Moreover, we predict that circadian PPIs dynamically connect many important cellular processes (signal transduction, cell cycle, etc.) contributing to temporal organization of cellular physiology in an unprecedented manner.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.