ArticlePLoS computational biology2013
Sparse distributed representation of odors in a large-scale olfactory bulb circuit.
Article in PLoS computational biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Ultrafast simulation of large-scale neocortical microcircuitry with biophysically realistic neurons.eLife · 2022Article
- Connectivity and dynamics in the olfactory bulb.PLoS computational biology · 2022Article
- Parallel odor processing by mitral and middle tufted cells in the olfactory bulb.Scientific reports · 2018Article
- Tracking traumatic head injuries with the chemical senses.World journal of otorhinolaryngology - head and neck surgery · 2018Review
- Synaptic E-I Balance Underlies Efficient Neural Coding.Frontiers in neuroscience · 2018Review
- Performance Comparison of the Digital Neuromorphic Hardware SpiNNaker and the Neural Network Simulation Software NEST for a Full-Scale Cortical Microcircuit Model.Frontiers in neuroscience · 2018Article
- Recognition of the Component Odors in Mixtures.Chemical senses · 2017Article
- The Theory of Localist Representation and of a Purely Abstract Cognitive System: The Evidence from Cortical Columns, Category Cells, and Multisensory Neurons.Frontiers in psychology · 2017Article
- Population imaging at subcellular resolution supports specific and local inhibition by granule cells in the olfactory bulb.Scientific reports · 2016Article
- Biophysical constraints on lateral inhibition in the olfactory bulb.Journal of neurophysiology · 2016Article
- Respiration Gates Sensory Input Responses in the Mitral Cell Layer of the Olfactory Bulb.PloS one · 2016Article
- Odor Experience Facilitates Sparse Representations of New Odors in a Large-Scale Olfactory Bulb Model.Frontiers in neuroanatomy · 2016Article
- Rapid Feedforward Inhibition and Asynchronous Excitation Regulate Granule Cell Activity in the Mammalian Main Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Bulbar microcircuit model predicts connectivity and roles of interneurons in odor coding.PloS one · 2015Article
- Sparse coding and lateral inhibition arising from balanced and unbalanced dendrodendritic excitation and inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Discharge patterning in rat olfactory bulb mitral cells in vivo.Physiological reports · 2014Article
- Distributed organization of a brain microcircuit analyzed by three-dimensional modeling: the olfactory bulb.Frontiers in computational neuroscience · 2014Article
- Electrical responses of three classes of granule cells of the olfactory bulb to synaptic inputs in different dendritic locations.Frontiers in computational neuroscience · 2014Article
- A spiking neural network model of self-organized pattern recognition in the early mammalian olfactory system.Frontiers in neural circuits · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
In the olfactory bulb, lateral inhibition mediated by granule cells has been suggested to modulate the timing of mitral cell firing, thereby shaping the representation of input odorants. Current experimental techniques, however, do not enable a clear study of how the mitral-granule cell network sculpts odor inputs to represent odor information spatially and temporally. To address this critical step in the neural basis of odor recognition, we built a biophysical network model of mitral and granule cells, corresponding to 1/100th of the real system in the rat, and used direct experimental imaging data of glomeruli activated by various odors. The model allows the systematic investigation and generation of testable hypotheses of the functional mechanisms underlying odor representation in the olfactory bulb circuit. Specifically, we demonstrate that lateral inhibition emerges within the olfactory bulb network through recurrent dendrodendritic synapses when constrained by a range of balanced excitatory and inhibitory conductances. We find that the spatio-temporal dynamics of lateral inhibition plays a critical role in building the glomerular-related cell clusters observed in experiments, through the modulation of synaptic weights during odor training. Lateral inhibition also mediates the development of sparse and synchronized spiking patterns of mitral cells related to odor inputs within the network, with the frequency of these synchronized spiking patterns also modulated by the sniff cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.