ArticlePLoS computational biology2013
A multi-scale analysis of influenza A virus fitness trade-offs due to temperature-dependent virus persistence.
Article in PLoS computational biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Quantifying the role of pre-existing tissue resident cellular immunity in limiting respiratory virus transmission.PLoS pathogens · 2026Article
- Modeling the effects of meteorological factors and media-driven public awareness on seasonal influenza outbreaks.PloS one · 2026Article
- Quantifying viral pandemic potential from experimental transmission studies.PLoS computational biology · 2025Article
- Host responses and viral traits interact to shape the impacts of climate warming on highly pathogenic avian influenza in migratory waterfowl.PLoS computational biology · 2025Article
- Quantifying viral pandemic potential from experimental transmission studies.bioRxiv : the preprint server for biology · 2025Article
- Optimal vaccination model of airborne infection under variable humidity and demographic heterogeneity for hybrid fractional operator technique.Scientific reports · 2025Article
- Terminating pandemics with smartwatches.PNAS nexus · 2025Article
- Modelling the transmission dynamics of H9N2 avian influenza viruses in a live bird market.Nature communications · 2024Article
- Correlation of viral loads in disease transmission could affect early estimates of the reproduction number.Journal of the Royal Society, Interface · 2023Article
- Challenges for modelling interventions for future pandemics.Epidemics · 2022Article
- Inferring environmental transmission using phylodynamics: a case-study using simulated evolution of an enteric pathogen.Journal of the Royal Society, Interface · 2021Article
- Optimizing the early detection of low pathogenic avian influenza H7N9 virus in live bird markets.Journal of the Royal Society, Interface · 2021Article
- Optimizing antiviral treatment for seasonal influenza in the USA: a mathematical modeling analysis.BMC medicine · 2021Article
- Cross-scale dynamics and the evolutionary emergence of infectious diseases.Virus evolution · 2021Article
- Energy Requirements for Loss of Viral Infectivity.Food and environmental virology · 2020Article
- A theoretical framework for transitioning from patient-level to population-scale epidemiological dynamics: influenza A as a case study.Journal of the Royal Society, Interface · 2020Article
- A Mathematical Framework for Predicting Lifestyles of Viral Pathogens.Bulletin of mathematical biology · 2020Article
- On modelling environmentally transmitted pathogens.Interface focus · 2020Article
- Improving risk assessment of the emergence of novel influenza A viruses by incorporating environmental surveillance.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- The Impact of Environmental Transmission and Epidemiological Features on the Geographical Translocation of Highly Pathogenic Avian Influenza Virus.International journal of environmental research and public health · 2019Article
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4 authors.
Funding
Abstract
Successful replication within an infected host and successful transmission between hosts are key to the continued spread of most pathogens. Competing selection pressures exerted at these different scales can lead to evolutionary trade-offs between the determinants of fitness within and between hosts. Here, we examine such a trade-off in the context of influenza A viruses and the differential pressures exerted by temperature-dependent virus persistence. For a panel of avian influenza A virus strains, we find evidence for a trade-off between the persistence at high versus low temperatures. Combining a within-host model of influenza infection dynamics with a between-host transmission model, we study how such a trade-off affects virus fitness on the host population level. We show that conclusions regarding overall fitness are affected by the type of link assumed between the within- and between-host levels and the main route of transmission (direct or environmental). The relative importance of virulence and immune response mediated virus clearance are also found to influence the fitness impacts of virus persistence at low versus high temperatures. Based on our results, we predict that if transmission occurs mainly directly and scales linearly with virus load, and virulence or immune responses are negligible, the evolutionary pressure for influenza viruses to evolve toward good persistence at high within-host temperatures dominates. For all other scenarios, influenza viruses with good environmental persistence at low temperatures seem to be favored.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.