ArticlePLoS computational biology2013
Angiogenesis: an adaptive dynamic biological patterning problem.
Article in PLoS computational biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed.
- Trial
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- Modeling of Singlet Oxygen Generation and Thermal Effects During Laser-Tissue Interaction.Materials (Basel, Switzerland) · 2025Article
- Multi-scale computational modeling towards efficacy in radiopharmaceutical therapies while minimizing side effects: Modeling of amino acid infusion.PLoS computational biology · 2025Article
- Sensitivity Analysis in the Problem of the Impact of an External Heat Impulse on Oxygen Distribution in Biological Tissue.Materials (Basel, Switzerland) · 2025Article
- Dysfunctional mechanotransduction regulates the progression of PIK3CA-driven vascular malformations.APL bioengineering · 2025Article
- Vascularization of human islets by adaptable endothelium for durable and functional subcutaneous engraftment.Science advances · 2025Article
- Dysfunctional mechanotransduction regulates the progression of PIK3CA-driven vascular malformations.bioRxiv : the preprint server for biology · 2024Article
- Mathematical models of developmental vascular remodelling: A review.PLoS computational biology · 2023Review
- Microcomputed tomography visualization and quantitation of the pulmonary arterial microvascular tree in mouse models of chronic lung disease.Pulmonary circulation · 2023Article
- Vein fate determined by flow-based but time-delayed integration of network architecture.eLife · 2023Article
- Image-based angio-adaptation modelling: a playground to study cerebrovascular development.Frontiers in physiology · 2023Article
- A proof-of-concept pipeline to guide evaluation of tumor tissue perfusion by dynamic contrast-agent imaging: Direct simulation and inverse tracer-kinetic procedures.Frontiers in bioinformatics · 2023Article
- Computational models for generating microvascular structures: Investigations beyond medical imaging resolution.WIREs mechanisms of disease · 2023Review
- Endothelialitis, Microischemia, and Intussusceptive Angiogenesis in COVID-19.Cold Spring Harbor perspectives in medicine · 2022Review
- Functional implications of microvascular heterogeneity for oxygen uptake and utilization.Physiological reports · 2022Review
- Network-driven anomalous transport is a fundamental component of brain microvascular dysfunction.Nature communications · 2021Article
- Modeling acute and chronic vascular responses to a major arterial occlusion.Microcirculation (New York, N.Y. : 1994) · 2021Article
- Numerical evaluation reveals the effect of branching morphology on vessel transport properties during angiogenesis.PLoS computational biology · 2021Article
1 more citing papers are in PubMed but not listed here.
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5 authors.
Funding
Abstract
Formation of functionally adequate vascular networks by angiogenesis presents a problem in biological patterning. Generated without predetermined spatial patterns, networks must develop hierarchical tree-like structures for efficient convective transport over large distances, combined with dense space-filling meshes for short diffusion distances to every point in the tissue. Moreover, networks must be capable of restructuring in response to changing functional demands without interruption of blood flow. Here, theoretical simulations based on experimental data are used to demonstrate that this patterning problem can be solved through over-abundant stochastic generation of vessels in response to a growth factor generated in hypoxic tissue regions, in parallel with refinement by structural adaptation and pruning. Essential biological mechanisms for generation of adequate and efficient vascular patterns are identified and impairments in vascular properties resulting from defects in these mechanisms are predicted. The results provide a framework for understanding vascular network formation in normal or pathological conditions and for predicting effects of therapies targeting angiogenesis.
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Registered trials
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