ArticleJournal of thyroid research2013
New insights into mechanisms of cardioprotection mediated by thyroid hormones.
Article in Journal of thyroid research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- Effect of Short-Term and Long-Term Non-Physiological T3 Concentrations on Cardiac Stromal Cells: From Cellular Response to In Vivo Adaptation.Medical sciences (Basel, Switzerland) · 2026Article
- Activity of Cardiomyocyte Type 3 Deiodinase After Myocardial Infarction Influences Cardiac Recovery in Females.Endocrinology · 2026Article
- The paradox of hypothyroidism: elevated cardiac biomarkers without coronary artery disease.Endocrinology, diabetes & metabolism case reports · 2025Article
- From Hypothyroidism to Coronary Heart Disease: Unraveling the Lipid Profile Link: A Mendelian Randomization Study.Journal of the Endocrine Society · 2025Article
- Influence of Mild Thyroid Dysfunction on Outcomes after Off-Pump Coronary Artery Bypass Surgery.Journal of clinical medicine · 2022Article
- Cardioprotection by post-conditioning with exogenous triiodothyronine in isolated perfused rat hearts and isolated adult rat cardiomyocytes.Basic research in cardiology · 2021Article
- Protective Effects of Thyroid Hormone Deprivation on Progression of Maladaptive Cardiac Hypertrophy and Heart Failure.Frontiers in cardiovascular medicine · 2021Article
- Impact of Hypothyroidism on Echocardiographic Characteristics of Patients With Heart Valve Disease: A Single-Center Propensity Score-Based Study.Frontiers in endocrinology · 2020Article
- The Role of Brown Adipose Tissue in Cardiovascular Disease Protection: Current Evidence and Future Directions.International journal of clinical research & trials · 2019Article
- Effect of levothyroxine on cardiac function in children with subclinical hypothyroidism: A quasi-experimental study.Caspian journal of internal medicine · 2019Article
- Free triiodothyronine and global registry of acute coronary events risk score on predicting long-term major adverse cardiac events in STEMI patients undergoing primary PCI.Lipids in health and disease · 2018Article
- Integrative analysis of differentially expressed genes and miRNAs predicts complex T3-mediated protective circuits in a rat model of cardiac ischemia reperfusion.Scientific reports · 2018Article
- Traditional Chinese medicine baoxin decoction improves cardiac fibrosis of rats with dilated cardiomyopathy.Experimental and therapeutic medicine · 2017Article
- Cardiac ACE2/angiotensin 1-7/Mas receptor axis is activated in thyroid hormone-induced cardiac hypertrophy.Therapeutic advances in cardiovascular disease · 2016Article
- Thyroid hormones and cardiac remodeling.Heart failure reviews · 2016Review
- Brown adipose tissue: The heat is on the heart.American journal of physiology. Heart and circulatory physiology · 2016Review
- Early and Short-term Triiodothyronine Supplementation Prevents Adverse Postischemic Cardiac Remodeling: Role of Transforming Growth Factor-β1 and Antifibrotic miRNA Signaling.Molecular medicine (Cambridge, Mass.) · 2016Article
- Gualou Xiebai decoction inhibits cardiac dysfunction and inflammation in cardiac fibrosis rats.BMC complementary and alternative medicine · 2016Article
- Overexpression myocardial inducible nitric oxide synthase exacerbates cardiac dysfunction and beta-adrenergic desensitization in experimental hypothyroidism.International journal of cardiology · 2016Article
- Native Magnetic Resonance T1-Mapping Identifies Diffuse Myocardial Injury in Hypothyroidism.PloS one · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heart failure represents the final common outcome in cardiovascular diseases. Despite significant therapeutic advances, morbidity and mortality of heart failure remain unacceptably high. Heart failure is preceded and sustained by a process of structural remodeling of the entire cardiac tissue architecture. Prevention or limitation of cardiac remodeling in the early stages of the process is a crucial step in order to ameliorate patient prognosis. Acquisition of novel pathophysiological mechanisms of cardiac remodeling is therefore required to develop more efficacious therapeutic strategies. Among all neuroendocrine systems, thyroid hormone seems to play a major homeostatic role in cardiovascular system. In these years, accumulating evidence shows that the "low triiodothyronine" syndrome is a strong prognostic, independent predictor of death in patients affected by both acute and chronic heart disease. In experimental models of cardiac hypertrophy or myocardial infarction, alterations in the thyroid hormone signaling, concerning cardiac mitochondrion, cardiac interstitium, and vasculature, have been suggested to be related to heart dysfunction. The aim of this brief paper is to highlight new developments in understanding the cardioprotective role of thyroid hormone in reverting regulatory networks involved in adverse cardiac remodeling. Furthermore, new recent advances on the role of specific miRNAs in thyroid hormone regulation at mitochondrion and interstitial level are also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.