ArticlePloS one2013
Subclinical thyroid dysfunction and cognitive decline in old age.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Subclinical Thyroid Dysfunction and the Risk of Cognitive Decline: a Meta-Analysis of Prospective Cohort Studies.The Journal of clinical endocrinology and metabolism · 2016Pooled it
- Higher FT4 or TSH below the normal range are associated with increased risk of dementia: a meta-analysis of 11 studies.Scientific reports · 2016Pooled it
- Thyrotropin and Alzheimer's Disease Risk in the Elderly: a Systematic Review and Meta-Analysis.Molecular neurobiology · 2016Pooled it
- Effects of Altering Levothyroxine (L-T4) Doses on Quality of Life, Mood, and Cognition in L-T4 Treated Subjects.The Journal of clinical endocrinology and metabolism · 2018Trial
- Subclinical thyroid dysfunction and functional capacity among elderly.Thyroid : official journal of the American Thyroid Association · 2014Trial
- Low levels of free triiodothyronine are associated with risk of cognitive impairment in older euthyroid adults.Scientific reports · 2023Article
- Resting Electroencephalography Differences Between Eyes-Closed and Eyes-Open Conditions in Children with Subclinical Hypothyroidism.Turkish archives of pediatrics · 2023Article
- Association of Hypothyroidism and the Risk of Cognitive Dysfunction: A Meta-Analysis.Journal of clinical medicine · 2022Review
- Neuropsychological Impairments in Young Patients With Subclinical Hypothyroidism: A Case Control Study.Annals of neurosciences · 2020Article
- Prevalence of thyroid dysfunction and its impact on cognition in older mexican adults: (SADEM study).Journal of endocrinological investigation · 2017Article
- Association between low thyroid-stimulating hormone, posterior cortical atrophy and nitro-oxidative stress in elderly patients with cognitive dysfunction.Archives of medical science : AMS · 2017Article
- Arthritis and Risk of Cognitive and Functional Impairment in Older Mexican Adults.Journal of aging and health · 2017Article
- Accelerated reduction of serum thyroxine and hippocampal histone acetylation links to exacerbation of spatial memory impairment in aged CD-1 mice pubertally exposed to bisphenol-a.Age (Dordrecht, Netherlands) · 2016Article
- Correlation of thyroid dysfunction and cognitive impairments induced by subcortical ischemic vascular disease.Brain and behavior · 2016Article
- Thyroid hormones are associated with longitudinal cognitive change in an urban adult population.Neurobiology of aging · 2015Article
- The 2015 European Thyroid Association Guidelines on Diagnosis and Treatment of Endogenous Subclinical Hyperthyroidism.European thyroid journal · 2015Article
- Possible role of glial cells in the relationship between thyroid dysfunction and mental disorders.Frontiers in cellular neuroscience · 2015Review
- Subclinical hypothyroidism and cognitive function in people over 60 years: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2015Review
- Psychiatric and cognitive manifestations of hypothyroidism.Current opinion in endocrinology, diabetes, and obesity · 2014Review
- Standards for thyroid laboratory testing, and cognitive functions after menopause.Przeglad menopauzalny = Menopause review · 2014Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSubclinical thyroid dysfunction has been implicated as a risk factor for cognitive decline in old age, but results are inconsistent. We investigated the association between subclinical thyroid dysfunction and cognitive decline in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER).
methodsProspective longitudinal study of men and women aged 70-82 years with pre-existing vascular disease or more than one risk factor to develop this condition (N = 5,154). Participants taking antithyroid medications, thyroid hormone supplementation and/or amiodarone were excluded. Thyroid function was measured at baseline: subclinical hyper- and hypothyroidism were defined as thyroid stimulating hormones (TSH) <0.45 mU/L or >4.50 mU/L respectively, with normal levels of free thyroxine (FT4). Cognitive performance was tested at baseline and at four subsequent time points during a mean follow-up of 3 years, using five neuropsychological performance tests.
resultsSubclinical hyperthyroidism and hypothyroidism were found in 65 and 161 participants, respectively. We found no consistent association of subclinical hyper- or hypothyroidism with altered cognitive performance compared to euthyroid participants on the individual cognitive tests. Similarly, there was no association with rate of cognitive decline during follow-up.
conclusionWe found no consistent evidence that subclinical hyper- or hypothyroidism contribute to cognitive impairment or decline in old age. Although our data are not in support of treatment of subclinical thyroid dysfunction to prevent cognitive dysfunction in later life, only large randomized controlled trials can provide definitive evidence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.