ArticlePloS one2013
Application of palladium-mediated (18)F-fluorination to PET radiotracer development: overcoming hurdles to translation.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 98 citations in OpenAlex.
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- Synthesis and Characterization of Palladium Pincer Bis(carbene) CCC Complexes.Organometallics · 2023Article
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- Radiosynthesis of the norepinephrine transporter tracer [Journal of labelled compounds & radiopharmaceuticals · 2019Article
- An azeotropic drying-free approach for copper-mediated radiofluorination without addition of base.Journal of labelled compounds & radiopharmaceuticals · 2019Article
- Chemistry for Positron Emission Tomography: Recent Advances inAngewandte Chemie (International ed. in English) · 2019Review
- Automated concentration of [Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2018Article
- Synthesis of [Angewandte Chemie (International ed. in English) · 2017Article
- Article
- Automation of the Radiosynthesis of Six DifferentEJNMMI radiopharmacy and chemistry · 2017Article
- Fluorine-18 patents (2009-2015). Part 2: new radiochemistry.Pharmaceutical patent analyst · 2016Review
- A Transmetalation Reaction Enables the Synthesis of [Organometallics · 2016Article
- Moving Metal-Mediated (18)F-Fluorination from Concept to Clinic.ACS central science · 2016Article
- Synthesis of [18F]Arenes via the Copper-Mediated [18F]Fluorination of Boronic Acids.Organic letters · 2015Article
- Synthesis and evaluation of 4-[18F]fluoropropoxy-3-iodobenzylguanidine ([18F]FPOIBG): A novel 18F-labeled analogue of MIBG.Nuclear medicine and biology · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
New chemistry methods for the synthesis of radiolabeled small molecules have the potential to impact clinical positron emission tomography (PET) imaging, if they can be successfully translated. However, progression of modern reactions from the stage of synthetic chemistry development to the preparation of radiotracer doses ready for use in human PET imaging is challenging and rare. Here we describe the process of and the successful translation of a modern palladium-mediated fluorination reaction to non-human primate (NHP) baboon PET imaging-an important milestone on the path to human PET imaging. The method, which transforms [(18)F]fluoride into an electrophilic fluorination reagent, provides access to aryl-(18)F bonds that would be challenging to synthesize via conventional radiochemistry methods.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.