ArticlePloS one2013
The effect of age and recent influenza vaccination history on the immunogenicity and efficacy of 2009-10 seasonal trivalent inactivated influenza vaccination in children.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Multivariate analysis of factors affecting the immunogenicity of trivalent inactivated influenza vaccine in school-age children.Epidemiology and infection · 2015Trial
- Poor sleep impairs immune responses and influenza vaccine protection.Nature communications · 2026Article
- Use of equine H3N8 hemagglutinin as a broadly protective influenza vaccine immunogen.NPJ vaccines · 2024Article
- Impact of host genetic polymorphisms on response to inactivated influenza vaccine in children.NPJ vaccines · 2023Article
- Challenges of Making Effective Influenza Vaccines.Annual review of virology · 2020Review
- Effect of Previous-Season Influenza Vaccination on Serologic Response in Children During 3 Seasons, 2013-2014 Through 2015-2016.Journal of the Pediatric Infectious Diseases Society · 2020Article
- Preexisting subtype immunodominance shapes memory B cell recall response to influenza vaccination.JCI insight · 2020Article
- Impaired Vaccine-Induced Antibody Response Against Clade 6B H1N1 Viruses in Individuals Before Viral Emergence.Open forum infectious diseases · 2020Article
- Effectiveness of Partial and Full Influenza Vaccination Among Children Aged <9 Years in Hong Kong, 2011-2019.The Journal of infectious diseases · 2019Article
- The Effects of Birth Year, Age and Sex on Hemagglutination Inhibition Antibody Responses to Influenza Vaccination.Vaccines · 2018Article
- Prior vaccinations improve immunogenicity of inactivated influenza vaccine in young children aged 6 months to 3 years: A cohort study.Medicine · 2018Observational
- Responders and non-responders to influenza vaccination: A DNA methylation approach on blood cells.Experimental gerontology · 2018Article
- Article
- Different Repeat Annual Influenza Vaccinations Improve the Antibody Response to Drifted Influenza Strains.Scientific reports · 2017Article
- The priming effect of previous natural pandemic H1N1 infection on the immunogenicity to subsequent 2010-2011 influenza vaccination in children: a prospective cohort study.BMC infectious diseases · 2016Article
- Preserved antiviral adaptive immunity following polyclonal antibody immunotherapy for severe murine influenza infection.Scientific reports · 2016Article
- Influenza Vaccine Effectiveness for Fully and Partially Vaccinated Children 6 Months to 8 Years Old During 2011-2012 and 2012-2013: The Importance of Two Priming Doses.The Pediatric infectious disease journal · 2016Article
- Trivalent influenza vaccine-induced antibody response to circulating influenza a (H3N2) viruses in 2010/11 and 2011/12 seasons.Human vaccines & immunotherapeutics · 2015Article
- Discordant correlation between serological assays observed when measuring heterosubtypic responses against avian influenza H5 and H7 viruses in unexposed individuals.BioMed research international · 2014Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThere is some evidence that annual vaccination of trivalent inactivated influenza vaccine (TIV) may lead to reduced vaccine immunogenicity but evidence is lacking on whether vaccine efficacy is affected by prior vaccination history. The efficacy of one dose of TIV in children 6-8 y of age against influenza B is uncertain. We examined whether immunogenicity and efficacy of influenza vaccination in school-age children varied by age and past vaccination history. METHODS AND
findingsWe conducted a randomized controlled trial of 2009-10 TIV. Influenza vaccination history in the two preceding years was recorded. Immunogenicity was assessed by comparison of HI titers before and one month after receipt of TIV/placebo. Subjects were followed up for 11 months with symptom diaries, and respiratory specimens were collected during acute respiratory illnesses to permit confirmation of influenza virus infections. We found that previous vaccination was associated with reduced antibody responses to TIV against seasonal A(H1N1) and A(H3N2) particularly in children 9-17 y of age, but increased antibody responses to the same lineage of influenza B virus in children 6-8 y of age. Serological responses to the influenza A vaccine viruses were high regardless of vaccination history. One dose of TIV appeared to be efficacious against confirmed influenza B in children 6-8 y of age regardless of vaccination history.
conclusionsPrior vaccination was associated with lower antibody titer rises following vaccination against seasonal influenza A vaccine viruses, but higher responses to influenza B among individuals primed with viruses from the same lineage in preceding years. In a year in which influenza B virus predominated, no impact of prior vaccination history was observed on vaccine efficacy against influenza B. The strains that circulated in the year of study did not allow us to study the effect of prior vaccination on vaccine efficacy against influenza A.
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