ArticlePloS one2013
Insect odorant response sensitivity is tuned by metabotropically autoregulated olfactory receptors.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 85 citations in OpenAlex.
- Graphene Nanosensor for the Detection of Small Organic Compounds Using an Insect Olfactory Receptor.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Sensitivity to cuticular hydrocarbons across the odorant receptor family in the Indian jumping ant,Frontiers in insect science · 2026Article
- Volatile Organic Compounds in Biological Matrices as a Sensitive Weapon in Cancer Diagnosis.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Type-specific molecular signaling architectures and synaptic plasticity ofFrontiers in cellular neuroscience · 2025Article
- Stimulus duration encoding occurs early in the moth olfactory pathway.Communications biology · 2024Article
- Response Plasticity ofInternational journal of molecular sciences · 2024Article
- High-throughput ligand profile characterization in novel cell lines expressing seven heterologous insect olfactory receptors for the detection of volatile plant biomarkers.Scientific reports · 2023Article
- Task-specific odorant receptor expression in worker antennae indicates that sensory filters regulate division of labor in ants.Communications biology · 2023Article
- Heterologous investigation of metabotropic and ionotropic odorant receptors in ab3A neurons ofFrontiers in molecular biosciences · 2023Article
- Modulation of the NO-cGMP pathway has no effect on olfactory responses in theFrontiers in cellular neuroscience · 2023Article
- Gain control in olfactory receptor neurons and the detection of temporal fluctuations in odor concentration.Frontiers in physiology · 2023Article
- Review
- Homeostasis of Mitochondrial CaInsects · 2022Article
- PKC98E Regulates Odorant Responses inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Impacts of OrX and cAMP-insensitive Orco to the insect olfactory heteromer activity.Molecular biology reports · 2021Article
- Altered functional properties of the codling moth Orco mutagenized in the intracellular loop-3.Scientific reports · 2021Article
- Calmodulin regulates the olfactory performance in Drosophila melanogaster.Scientific reports · 2021Article
- Transduction and Adaptation Mechanisms in the Cilium or Microvilli of Photoreceptors and Olfactory Receptors From Insects to Humans.Frontiers in cellular neuroscience · 2021Review
- Functional properties of insect olfactory receptors: ionotropic receptors and odorant receptors.Cell and tissue research · 2021Review
- Molecular mechanisms of olfactory detection in insects: beyond receptors.Open biology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insects possess one of the most exquisitely sensitive olfactory systems in the animal kingdom, consisting of three different types of chemosensory receptors: ionotropic glutamate-like receptors (IRs), gustatory receptors (GRs) and odorant receptors (ORs). Both insect ORs and IRs are ligand-gated ion channels, but ORs possess a unique configuration composed of an odorant-specific protein OrX and a ubiquitous coreceptor (Orco). In addition, these two ionotropic receptors confer different tuning properties for the neurons in which they are expressed. Unlike IRs, neurons expressing ORs are more sensitive and can also be sensitized by sub-threshold concentrations of stimuli. What is the mechanistic basis for these differences in tuning? We show that intrinsic regulation of Orco enhances neuronal response to odorants and sensitizes the ORs. We also demonstrate that inhibition of metabotropic regulation prevents receptor sensitization. Our results indicate that Orco-mediated regulation of OR sensitivity provides tunable ionotropic receptors capable of detecting odors over a wider range of concentrations, providing broadened sensitivity over IRs themselves.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.