ArticlePloS one2013
Correlation of immunoglobulin G expression and histological subtype and stage in breast cancer.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 52 citations in OpenAlex.
- Anti-SIA-cIgG enhances chemotherapy effectiveness through PTPN13-regulated tumor stemness in head and neck squamous cell carcinoma.Journal of translational internal medicine · 2026Article
- B-cells and non-B-cells immunoglobulins expression in canine perianal gland tumours: a preliminary study.Frontiers in veterinary science · 2025Article
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- Non B Cell-Derived Immunoglobulins in Lung Epithelial Cells and Lung Cancer.Advances in experimental medicine and biology · 2024Review
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- The Expression of Non B Cell-Derived Immunoglobulins.Advances in experimental medicine and biology · 2024Review
- Comparison of Non B-Ig and B-Ig.Advances in experimental medicine and biology · 2024Review
- Expression and Clinical Significance of Non B Cell-Derived Immunoglobulins in the Urinary System and Male Reproductive System.Advances in experimental medicine and biology · 2024Review
- Expression and Function of Mammary Epithelial Cell-Derived Immunoglobulins.Advances in experimental medicine and biology · 2024Review
- IGHG1 promotes malignant progression in breast cancer cells through the regulation of AKT and VEGF signaling.Biomolecules & biomedicine · 2023Article
- Clinical and biological heterogeneities in triple-negative breast cancer reveals a non-negligible role of HER2-low.Breast cancer research : BCR · 2023Article
- B Cells in Breast Cancer Pathology.Cancers · 2023Review
- Does TLS Exist in Canine Mammary Gland Tumours? Preliminary Results in Simple Carcinomas.Veterinary sciences · 2022Article
- SIA-IgG confers poor prognosis and represents a novel therapeutic target in breast cancer.Bioengineered · 2022Article
- Relationship between Prognosis, Immune Infiltration Level, and Differential Expression of PARVG Gene in Uterine Corpus Endometrial Carcinoma.Contrast media & molecular imaging · 2022Article
- Development of Dl1.72, a Novel Anti-DLL1 Antibody with Anti-Tumor Efficacy against Estrogen Receptor-Positive Breast Cancer.Cancers · 2021Article
- Current insights into the expression and functions of tumor-derived immunoglobulins.Cell death discovery · 2021Review
- Immune Cells and Immunoglobulin Expression in the Mammary Gland Tumors of Dog.Animals : an open access journal from MDPI · 2021Article
- Down-regulation of IGHG1 enhances Protoporphyrin IX accumulation and inhibits hemin biosynthesis in colorectal cancer by suppressing the MEK-FECH axis.Open life sciences · 2021Article
- Immunoglobulin Expression in Cancer Cells and Its Critical Roles in Tumorigenesis.Frontiers in immunology · 2021Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRecently, growing evidence indicates that immunoglobulins (Igs) are not only produced by mature B lymphocytes or plasma cells, but also by various normal cells types at immune privileged sites and neoplasm, including breast cancer. However, the association of breast cancer derived IgG with genesis and development of the disease has not yet been established.
methodsIn this study we examined the expression of IgG in 186 breast cancers, 20 benign breast lesions and 30 normal breast tissues. Both immunohistochemistry with antibodies to Igκ (immunoglobulin G κ light chain) and Igγ (immunoglobulin G heavy chain) and in situ hybridization with an antisense probe to IgG1 heavy chain constant region gene were performed. Various clinicopathological features were also analyzed.
resultsWe found that IgG is specifically expressed in human breast cancer cells. Both infiltrating ductal carcinoma and infiltrating lobular carcinoma had significantly greater numbers of Igκ and Igγ positive cancer cells as compared with medullary carcinoma, carcinoma in situ, and benign lesions (all p<0.05). In addition, IgG expression was correlated with breast cancer histological subtypes (p<0.01) and AJCC stages (p<0.05), with more abundance of IgG expression in more malignant histological subtypes or in more advanced stage of the disease.
conclusionsIgG expression in breast cancer cells is correlated with malignancy and AJCC stages of the cancers. This suggests that breast cancer derived IgG may be associated with genesis, development and prognosis of the cancer.
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