ArticlePloS one2013
N, N'-Olefin functionalized bis-imidazolium gold(I) salt is an efficient candidate to control keratitis-associated eye infection.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 66 citations in OpenAlex.
- Exploring a Therapeutic Gold Mine: The Antifungal Potential of the Gold-Based Antirheumatic Drug Auranofin.International journal of molecular sciences · 2025Review
- Enhancing the therapeutical potential of metalloantibiotics using nano-based delivery systems.Beilstein journal of nanotechnology · 2025Review
- Article
- Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes.Pharmaceutics · 2023Review
- Gold drugs as colistin adjuvants in the fight against MCR-1 producing bacteria.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2023Article
- Novel gold(III)-dithiocarbamate complex targeting bacterial thioredoxin reductase: antimicrobial activity, synergy, toxicity, and mechanistic insights.Frontiers in microbiology · 2023Article
- Gold(III) Complexes Activity against Multidrug-Resistant Bacteria of Veterinary Significance.Antibiotics (Basel, Switzerland) · 2022Article
- Biological Activity of NHC-Gold-Alkynyl Complexes Derived from 3-Hydroxyflavones.Pharmaceutics · 2022Article
- Green Synthesis, Characterization, Antimicrobial and Anticancer Screening of New Metal Complexes Incorporating Schiff Base.ACS omega · 2022Article
- Gold-Derived Molecules as New Antimicrobial Agents.Frontiers in microbiology · 2022Review
- A CFrontiers in microbiology · 2022Article
- An Organogold Compound as Potential Antimicrobial Agent against Drug-Resistant Bacteria: Initial Mechanistic Insights.ChemMedChem · 2021Article
- Selective cytotoxicity and antifungal properties of copper(II) and cobalt(II) complexes with imidazole-4-acetate anion or 1-allylimidazole.Scientific reports · 2019Article
- Curd-Peptide Based Novel Hydrogel Inhibits Biofilm Formation, Quorum Sensing, Swimming Mortility of Multi-Antibiotic Resistant Clinical Isolates and Accelerates Wound Healing Activity.Frontiers in microbiology · 2019Article
- Discovery of Distinctin-Like-Peptide-PH (DLP-PH) From the Skin Secretion ofFrontiers in microbiology · 2018Article
- 1-((2,4-Dichlorophenethyl)Amino)-3-Phenoxypropan-2-ol KillsFrontiers in microbiology · 2018Article
- Lignin-graft-Polyoxazoline Conjugated Triazole a Novel Anti-Infective Ointment to Control Persistent Inflammation.Scientific reports · 2017Article
- Targeted Modification of a Novel Amphibian Antimicrobial Peptide fromFrontiers in microbiology · 2017Article
- Glucose directly promotes antifungal resistance in the fungal pathogen, Candida spp.The Journal of biological chemistry · 2014Article
- Purification, biochemical characterization and self-assembled structure of a fengycin-like antifungal peptide from Bacillus thuringiensis strain SM1.Frontiers in microbiology · 2013Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Keratitis treatment has become more complicated due to the emergence of bacterial or fungal pathogens with enhanced antibiotic resistance. The pharmaceutical applications of N-heterocyclic carbene complexes have received remarkable attention due to their antimicrobial properties. In this paper, the new precursor, 3,3'-(p-phenylenedimethylene) bis{1-(2- methyl-allyl)imidazolium} bromide (1a) and its analogous PF6 salt (1b) were synthesized. Furthermore, silver(I) and gold(I) -N-heterocyclic carbene (NHC) complexes [Ag2LBr2/Au2LBr2; 2a/3a], [(Ag2L2)(PF6)2/(Au2L2)(PF6)2; 2b/3b] were developed from their corresponding ligands. All compounds were screened for their antimicrobial activities against multiple keratitis-associated human eye pathogens, including bacteria and fungi. Complexes 2a and 3a showed highest activity, and the effectiveness of 3a was also studied, focusing eradication of pathogen biofilm. Furthermore, the structures of 1a, 2a and 3b were determined using single crystal X-ray analysis, 2b and 3a were optimized theoretically. The mechanism of action of 3a was evaluated by scanning electron microscopy and docking experiments, suggesting that its target is the cell membrane. In summary, 3a may be helpful in developing antimicrobial therapies in patients suffering from keratitis-associated eye infections caused by multidrug-resistant pathogens.
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