ArticlePloS one2013
Genetic predisposition to pass the standard SICCT test for bovine tuberculosis in British cattle.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Studies on the immunological biomarkers of bovine tuberculosis in naturally infected cattle.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Integrative genomics sheds light on the immunogenetics of tuberculosis in cattle.Communications biology · 2025Article
- Screening of mRNA markers in early bovine tuberculosis blood samples.Frontiers in veterinary science · 2024Article
- Transcriptional Profiling of Early and Late Phases of Bovine Tuberculosis.Infection and immunity · 2022Article
- Evaluation of Three Commercial Interferon-γ Assays in a Bovine Tuberculosis Free Population.Frontiers in veterinary science · 2021Article
- Genetic Diversity of Cameroon Cattle and a Putative Genomic Map for Resistance to Bovine Tuberculosis.Frontiers in genetics · 2020Article
- Exploring the Risk Posed by Animals with an Inconclusive Reaction to the Bovine Tuberculosis Skin Test in England and Wales.Veterinary sciences · 2019Article
- An analysis of effects of heterozygosity in dairy cattle for bovine tuberculosis resistance.Animal genetics · 2018Article
- Evaluating diagnostic tests for bovine tuberculosis in the southern part of Germany: A latent class analysis.PloS one · 2017Article
- Quantitative genetic analysis of the bTB diagnostic single intradermal comparative cervical test (SICCT).Genetics, selection, evolution : GSE · 2016Article
- A review of risk factors for bovine tuberculosis infection in cattle in the UK and Ireland.Epidemiology and infection · 2016Review
- Evaluation of complementary diagnostic tools for bovine tuberculosis detection in dairy herds from India.Veterinary world · 2016Article
- Herd-level bovine tuberculosis risk factors: assessing the role of low-level badger population disturbance.Scientific reports · 2015Article
- Statement on a conceptual framework for bovine tuberculosis.EFSA journal. European Food Safety Authority · 2014Article
- Field-isolated genotypes of Mycobacterium bovis vary in virulence and influence case pathology but do not affect outbreak size.PloS one · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bovine tuberculosis (bTB) imposes an important financial burden on the British cattle industry, yet despite intense efforts to control its spread, incidence is currently rising. Surveillance for bTB is based on a skin test that measures an immunological response to tuberculin. Cattle that fail the test are classified as "reactors" and slaughtered. Recent studies have identified genetic markers associated with the reaction of cattle to the tuberculin test. At marker INRA111 a relatively common '22' genotype occurs significantly more frequently in non-reactor cattle. Here we test the possibility that the putative protective '22' genotype does not confer resistance but instead causes cattle that carry it to react less strongly to the prescribed test, and hence avoid slaughter, potentially even though they are infected. We show that, after controlling for age and breed, '22' cattle react less strongly to the immunological challenge and may therefore be less likely to be classified as a reactor. These results highlight the potential discrepancy between infection and test status and imply that the effectiveness of the test-and-slaughter policy may be being compromised by selection for cattle that are genetically predisposed to react less strongly to tuberculin.
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