ArticleEvidence-based complementary and alternative medicine : eCAM2013
Inflammatory Regulation Effect and Action Mechanism of Anti-Inflammatory Effective Parts of Housefly (Musca domestica) Larvae on Atherosclerosis.
Article in Evidence-based complementary and alternative medicine : eCAM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Low-Molecular-Weight Peptides fromInternational journal of molecular sciences · 2026Article
- Response Surface Methodology (RSM) for Optimizing Protein Extraction from Housefly (Molecules (Basel, Switzerland) · 2024Article
- Comparison of the antioxidant activities of nonfumigated and sulphur-fumigatedPharmaceutical biology · 2021Article
- Enhanced Antioxidant and Cytotoxic Potentials of Lipopolysaccharides-InjectedPharmaceutics · 2020Article
- Identification of proteins in housefly (RSC advances · 2019Article
- Protein-rich extract ofJournal of biosciences · 2018Article
- Immunological adjuvant effect of the peptide fraction from the larvae of Musca domestica.BMC complementary and alternative medicine · 2015Article
- Antihepatitis B virus activity of a protein-enriched fraction from housefly (Musca domestica) in a stable HBV-producing cell line.TheScientificWorldJournal · 2014Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The protein-enriched extracts of housefly larvae were segregated by gel-filtration chromatography (GFC) and then anti-inflammatory activity screening in RAW264.7 (induced by LPS) was carried out. After acquire the anti-inflammatory effective parts, its anti-atherosclerotic properties in vivo were then evaluated. Results showed that the anti-inflammatory effective parts of housefly larvae were low-molecular-weight parts. After treated with the effective parts oral gavaged for 4 weeks, the atherosclerotic lesions of the mouse were significantly decreased. The inflammatory and lipid parameters were also reduced (except HDL which was increased). Western blot analysis demonstrated that the effective parts exerted potent inhibitory effect on expression of p65 in nucleus and cytoplasm. The results of immunofluorescence microscopy analysis also showed that the expressions of p65 both in cytoplasm and nucleus were significantly reduced. The hypothesis that the anti-inflammatory effective parts of housefly larvae possessed anti-atherosclerosis activity in mouse and the possible mechanism could be associated with the inhibition of expression and nuclear transfer of NF- κ B p65 could be derived.
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Registered trials
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