ArticlePPAR research2013
The Role of PPARs in Placental Immunology: A Systematic Review of the Literature.
Article in PPAR research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
12 citing papers in PubMed.
- Biological networks in gestational diabetes mellitus: insights into the mechanism of crosstalk between long non-coding RNA and NBMC pregnancy and childbirth · 2022Article
- Association study of rs1801282 PPARG gene polymorphism and immune cells and cytokine levels in a Spanish pregnant women cohort and their offspring.Journal of biomedical science · 2020Article
- Human Endometrial Stromal Cell Differentiation is Stimulated by PPARβ/δ Activation: New Targets for Infertility?The Journal of clinical endocrinology and metabolism · 2020Article
- PPARγ Expression Is Diminished in Macrophages of Recurrent Miscarriage Placentas.International journal of molecular sciences · 2018Article
- Prostaglandin EEndocrine connections · 2018Article
- Relationship ofOncoTargets and therapy · 2018Article
- PPARG c.1347C>T polymorphism is associated with cancer susceptibility: from a case-control study to a meta-analysis.Oncotarget · 2017Article
- Preimplantation factor is an anti-apoptotic effector in human trophoblasts involving p53 signaling pathway.Cell death & disease · 2016Article
- RXRα is upregulated in first trimester endometrial glands of spontaneous abortions unlike LXR and PPARγ.European journal of histochemistry : EJH · 2016Article
- Peroxisome proliferator-activated receptor gamma (PPARG) rs1801282 C>G polymorphism is associated with cancer susceptibility in asians: an updated meta-analysis.International journal of clinical and experimental medicine · 2015Article
- High Levels of Perfluorooctane Sulfonate in Children at the Onset of Diabetes.International journal of endocrinology · 2015Article
- Roles of PPARγ/NF-κB signaling pathway in the pathogenesis of intrahepatic cholestasis of pregnancy.PloS one · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pregnancy is a state of immunotolerance, and pregnancy outcome is strongly linked to the correct activation and balancing of the maternal immune system. Besides abortion as possible result of improper early pregnancy development, other pregnancy associated conditions like preeclampsia (PE), intrauterine growth retardation (IUGR), preterm labour, or gestational diabetes mellitus (GDM) are linked to immunologic overactivation and dysregulation. Both the innate and the adaptive immune system, and therefore B and T lymphocytes, natural killer cells (NK), macrophages and dendritic cells (DCs) are all involved in trophoblast invasion, pregnancy maintenance, and development of pregnancy disorders. Peroxisome proliferator activated receptors (PPARs) are nuclear transcription factors with three known isotypes: PPARα, PPAR β / δ , and PPAR γ . They are expressed in most human organs and their function extends from regulating metabolism, homeostasis, and carcinogenesis to immune response. In the recent years, PPARs have been identified in most reproductive tissues and in all lines of immune cells. Only in few cases, the role of PPARs in reproductive immunology has been elucidated though the role of PPARs in immune answer and immunotolerance is evident. Within this paper we would like to give an update on today's knowledge about PPARs and immune cells in reproduction and highlight interesting interferences in regard of future therapeutic targets.
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Registered trials
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