ArticleJournal of biomedical research2012
MiRNA-429 suppresses the growth of gastric cancer cells in vitro.
Article in Journal of biomedical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- The role of miR-200 family in the regulation of hallmarks of cancer.Frontiers in oncology · 2022Review
- HIF1A-AS2 Promotes the Proliferation and Metastasis of Gastric Cancer Cells Through miR-429/PD-L1 Axis.Digestive diseases and sciences · 2021Article
- Circular RNA circRNA_0082835 promotes progression and lymphatic metastasis of primary melanoma by sponging microRNA miRNA-429.Bioengineered · 2021Article
- Linc00641 promotes the progression of gastric carcinoma by modulating the miR-429/Notch-1 axis.Aging · 2021Article
- The inhibiting effects of microRNA-429 on the progression of pancreatic ductal adenocarcinoma cells by inhibiting epithelial mesenchymal transition.American journal of translational research · 2021Article
- MicroRNA-429 inhibits neuroblastoma cell proliferation, migration and invasion via the NF-κB pathway.Cellular & molecular biology letters · 2020Article
- Identification of key pathways and genes in endometrial cancer using bioinformatics analyses.Oncology letters · 2019Article
- LncRNA HOXA11-AS drives cisplatin resistance of human LUAD cells via modulating miR-454-3p/Stat3.Cancer science · 2018Article
- Soft-shelled turtle peptide modulates microRNA profile in human gastric cancer AGS cells.Oncology letters · 2018Article
- MicroRNA-429 decreases the invasion ability of gastric cancer cell line BGC-823 by downregulating the expression of heparanase.Experimental and therapeutic medicine · 2018Article
- Reduction of miR‑132‑3p contributes to gastric cancer proliferation by targeting MUC13.Molecular medicine reports · 2017Article
- Downregulation of miR-429 contributes to the development of drug resistance in epithelial ovarian cancer by targeting ZEB1.American journal of translational research · 2017Article
- miR-429 promotes the proliferation of non-small cell lung cancer cells via targeting DLC-1.Oncology letters · 2016Article
- Exosome-derived microRNAs contribute to prostate cancer chemoresistance.International journal of oncology · 2016Article
- MiR-493 suppresses the proliferation and invasion of gastric cancer cells by targeting RhoC.Iranian journal of basic medical sciences · 2015Article
- MicroRNAs in tumorigenesis, metastasis, diagnosis and prognosis of gastric cancer.Cancer gene therapy · 2015Review
- MicroRNA-204-5p inhibits gastric cancer cell proliferation by downregulating USP47 and RAB22A.Medical oncology (Northwood, London, England) · 2015Article
- MicroRNA Expression Profiling in Clear Cell Renal Cell Carcinoma: Identification and Functional Validation of Key miRNAs.PloS one · 2015Article
- miR-101 inhibits cell proliferation by targeting Rac1 in papillary thyroid carcinoma.Biomedical reports · 2014Article
- Identification of Aberrantly Expressed miRNAs in Gastric Cancer.Gastroenterology research and practice · 2014Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Micro-RNAs (miRNAs) have been found to be implicated in a very wide range of physiological processes. This study was aimed to investigate the regulation of miRNA-429 (miR-429) in gastric cancer cells on cell proliferation and apoptosis. Quantitative PCR was employed to detect the expressions of miR-429 after eukaryotic expression plasmid of miR-429 and its inhibitor were transiently transfected into poorly differentiated human gastric cancer cell line BGC823. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction assays were used to examine proliferation ability. Apoptosis was analyzed by flow cytometry after transfection. The results showed that 48 h after transfection, overexpression of miR-429 reached maximum efficiency. Compared with mock transfection, miR-429 inhibited tumor cell proliferation significantly (P < 0.05) at 48 h and 72 h. of Overexpression of miR-429 promoted tumor cell apoptosis when compared with mock transfected cells (P < 0.05). On the contrary, miR-429 inhibitor promoted tumor cell proliferation and inhibited apoptosis when compared with controls (P < 0.05). Our results suggested that miRNA-429 may serve as a tumor suppressor during tumorigenesis of gastric cancer and may be a potential gastric cancer therapeutic target.
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Registered trials
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