ArticleJournal of biomedical research2012
Telmisartan prevents high-fat diet-induced hypertension and decreases perirenal fat in rats.
Article in Journal of biomedical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Oleanolic acid attenuates obesity through modulating the lipid metabolism in high-fat diet-fed mice.Food science & nutrition · 2024Article
- Galangin Resolves Cardiometabolic Disorders through Modulation of AdipoR1, COX-2, and NF-κB Expression in Rats Fed a High-Fat Diet.Antioxidants (Basel, Switzerland) · 2021Article
- Countering adipose tissue dysfunction could underlie the superiority of telmisartan in the treatment of obesity-related hypertension.Cardiovascular diabetology · 2021Article
- Biochemical and nutritional overview of diet-induced metabolic syndrome models in rats: what is the best choice?Nutrition & diabetes · 2020Review
- The Role of a Selective P2YBioMed research international · 2020Article
- Article
- High fat diet confers vascular hyper-contractility against angiotensin II through upregulation of MLCK and CPI-17.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2017Article
- Antihypertensive drug Valsartan promotes dendritic spine density by altering AMPA receptor trafficking.Biochemical and biophysical research communications · 2013Article
- Perirenal Adipose Tissue: Clinical Implication and Therapeutic Interventions.Indian journal of nephrologyReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We sought to investigate the effects of telmisartan on high-fat diet-induced hypertension and to explore the possible underlying mechanisms. Rats receiving high-fat diet were randomly divided into two groups, the telmisartan group (n = 9) and the high-fat diet group (n = 10). The control group consisted of age-matched rats on a regular diet (n = 10). At the end of the treatment, the body weight, blood pressure, insulin sensitivity and serum adiponectin levels of all rats were examined, and their visceral fat was extracted and weighed. Our results showed that telmisartan improved insulin resistance and dyslipidemia and increased serum adiponectin levels. Telmisartan also lowered both systolic blood pressure and diastolic blood pressure, and decreased the accumulation of perirenal fat associated with high-fat diet. Furthermore, telmisartan increased adiponectin mRNA expression in the perirenal fat. Correlation analysis showed that both systolic blood pressure and diastolic blood pressure were positively correlated with perirenal fat. These effects of telmisartan may be mediated through decreases in perirenal fat and contributed to the improvement of perirenal fat function. Our findings suggested a strong link between perirenal fat and high-fat diet-induced hypertension, and identified telmisartan as a potential drug for the treatment of obesity-related hypertension.
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