ArticleMetabolomics : Official journal of the Metabolomic Society2013
Large-scale neurochemical metabolomics analysis identifies multiple compounds associated with methamphetamine exposure.
Article in Metabolomics : Official journal of the Metabolomic Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Article
- Impact of Substance Use Disorder on Tryptophan Metabolism Through the Kynurenine Pathway: A Narrative Review.Metabolites · 2024Review
- Article
- Review
- Identification of Biomarkers for Methamphetamine Exposure Time Prediction in Mice Using Metabolomics and Machine Learning Approaches.Metabolites · 2022Article
- Brain lipidomics: From functional landscape to clinical significance.Science advances · 2022Review
- Article
- Ergothioneine: A Stress Vitamin with Antiaging, Vascular, and Neuroprotective Roles?Antioxidants & redox signaling · 2022Review
- The Potential Regulatory Network of Glutamate Metabolic Pathway Disturbance in Chinese Han Withdrawal Methamphetamine Abusers.Frontiers in genetics · 2021Article
- Immune System and Methamphetamine: Molecular Basis of a Relationship.Current neuropharmacology · 2021Article
- Revealing Metabolic Perturbation Following Heavy Methamphetamine Abuse by Human Hair Metabolomics and Network Analysis.International journal of molecular sciences · 2020Article
- Metabolomics Approach Reveals the Effects of Breed and Feed on the Composition of Chicken Eggs.Metabolites · 2019Article
- Current Understanding of Methamphetamine-Associated Metabolic Changes Revealed by the Metabolomics Approach.Metabolites · 2019Review
- Tremorgenic effects and functional metabolomics analysis of lolitrem B and its biosynthetic intermediates.Scientific reports · 2019Article
- Metabolomic Strategies in Biomarker Research-New Approach for Indirect Identification of Drug Consumption and Sample Manipulation in Clinical and Forensic Toxicology?Frontiers in chemistry · 2019Review
- Reduced carboxylesterase 1 is associated with endothelial injury in methamphetamine-induced pulmonary arterial hypertension.American journal of physiology. Lung cellular and molecular physiology · 2017Article
- Circadian Time Structure of Circulating Plasma Lipid Components in Healthy Indians of Different Age Groups.Indian journal of clinical biochemistry : IJCB · 2016Article
- Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain.Neurobiology of aging · 2015Article
- NMR-Based Metabolic Profiling Reveals Neurochemical Alterations in the Brain of Rats Treated with Sorafenib.Neurotoxicity research · 2015Article
- Neurochemical Metabolomics Reveals Disruption to Sphingolipid Metabolism Following Chronic Haloperidol Administration.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Methamphetamine (MA) is an illegal stimulant drug of abuse with serious negative health consequences. The neurochemical effects of MA have been partially characterized, with a traditional focus on classical neurotransmitter systems. However, these directions have not yet led to novel drug treatments for MA abuse or toxicity. As an alternative approach, we describe here the first application of metabolomics to investigate the neurochemical consequences of MA exposure in the rodent brain. We examined single exposures at 3 mg/kg and repeated exposures at 3 mg/kg over 5 days in eight common inbred mouse strains. Brain tissue samples were assayed using high-throughput gas and liquid chromatography mass spectrometry, yielding quantitative data on >300 unique metabolites. Association testing and false discovery rate control yielded several metabolome-wide significant associations with acute MA exposure, including compounds such as lactate (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.