ArticleInterdisciplinary toxicology2012
Teratology - past, present and future.
Article in Interdisciplinary toxicology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- The First Steps on AOPs' Concepts, Development, and Applications in Teratology.Methods in molecular biology (Clifton, N.J.) · 2024Pooled it
- From teratogens to trajectories: Integrating teratology and Developmental Origins of Health and Disease (DOHaD) frameworks for a new take on fetal alcohol spectrum disorders (FASD).Neurobiology of stress · 2026Article
- Global bibliometric insights on prenatal exposures and pregnancy outcomes.Northern clinics of Istanbul · 2025Article
- Vascular Diseases in Women: Do Women Suffer from Them Differently?Journal of clinical medicine · 2024Review
- The Future of the Teratogenicity Testing.Methods in molecular biology (Clifton, N.J.) · 2024Review
- Exploration of Teratogenic and Genotoxic Effects on Model Organism Drosophila melanogaster.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Monocephalus dipygus in a 4-month-old mixed-breed puppy: clinical, radiographic, ultrasonographic, karyotyping and surgical intervention.International journal of veterinary science and medicine · 2024Article
- Updating an Overview of Teratology.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Dolutegravir Impairs Stem Cell-Based 3D Morphogenesis Models in a Manner Dependent on Dose and Timing of Exposure: An Implication for Its Developmental Toxicity.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Congenital Malformations in Sea Turtles: Puzzling Interplay between Genes and Environment.Animals : an open access journal from MDPI · 2021Review
- Teratological changes in postembryos ofPeerJ · 2021Article
- From the Farm to the Lab: How Chicken Embryos Contribute to the Field of Teratology.Frontiers in genetics · 2021Review
- Inappropriate modeling of chronic and complex disorders: How to reconsider the approach in the context of predictive, preventive and personalized medicine, and translational medicine.The EPMA journal · 2019Article
- How can the process of postnatal adaptation be changed by the presence of congenital abnormalities of lip and palate.Interdisciplinary toxicology · 2017Article
- Comment on "Identifying Human Teratogens: An Update".Journal of pediatric genetics · 2016Article
- Effect of non-ionizing electromagnetic field on the alteration of ovarian follicles in rats.Electronic physician · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Teratology is the science that studies the causes, mechanisms, and patterns of abnormal development. The authors present an updated overview of the most important milestones and stages of the development of modern teratology. Development of knowledge and society led to the recognition that causes of congenital developmental disorders (CDDs) might be caused by various mechanical effects, foetal diseases, and retarded or arrested development of the embryo and foetus. Based on the analysis of the historical development of hypotheses and theories representing a decisive contribution to this field, we present a survey of the six Wilson's fundamental principles of teratology. The aim of observing these principles is to get insight into developmental relations and to understand mechanisms of action on the level of cell populations (elementary morphogenetic processes), tissues and organs. It is important to realise that any negative intervention into the normal course of these processes, either on genetic or non-genetic basis, inevitably leads to a sequence of subsequent changes resulting in CDDs. Moreover, the classical toxicologic monotonic dose-response paradigm recently has been challenged by the so-called "low dose-hypothesis", particularly in the case of endocrine active substances. These include some pesticides, dioxins, polychlorobiphenyls (PCBs), and bisphenol A. Despite modern approaches of molecular biology and genetics, along with top diagnostic techniques, we are still not able to identify the actual cause in more than 65 to 70% of all congenital defects classified as having an unknown etiology. Today CDDs include any birth defect, either morphological, biochemical, or behavioural.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.