ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Entorhinal stellate cells show preferred spike phase-locking to theta inputs that is enhanced by correlations in synaptic activity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 21 citations in OpenAlex.
- Large time step discrete-time modeling of sharp wave activity in hippocampal area CA3.Communications in nonlinear science & numerical simulation · 2019Article
- Post-Inhibitory Rebound Spikes in Rat Medial Entorhinal Layer II/III Principal Cells: In Vivo, In Vitro, and Computational Modeling Characterization.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Heterosynaptic modulation of evoked synaptic potentials in layer II of the entorhinal cortex by activation of the parasubiculum.Journal of neurophysiology · 2016Article
- Hippocampal CA1 Ripples as Inhibitory Transients.PLoS computational biology · 2016Article
- Synaptic Targets of Medial Septal Projections in the Hippocampus and Extrahippocampal Cortices of the Mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Rebound spiking properties of mouse medial entorhinal cortex neurons in vivo.The European journal of neuroscience · 2015Article
- Non-linear Membrane Properties in Entorhinal Cortical Stellate Cells Reduce Modulation of Input-Output Responses by Voltage Fluctuations.PLoS computational biology · 2015Article
- Proximodistal structure of theta coordination in the dorsal hippocampus of epileptic rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Membrane potential-dependent integration of synaptic inputs in entorhinal stellate neurons.Hippocampus · 2014Article
- Elevated serotonergic signaling amplifies synaptic noise and facilitates the emergence of epileptiform network oscillations.Journal of neurophysiology · 2014Article
- Frequency preference in two-dimensional neural models: a linear analysis of the interaction between resonant and amplifying currents.Journal of computational neuroscience · 2014Article
- The past, present, and future of real-time control in cellular electrophysiology.IEEE transactions on bio-medical engineering · 2014Review
- How to build a grid cell.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Nonlinear properties of medial entorhinal cortex neurons reveal frequency selectivity during multi-sinusoidal stimulation.Frontiers in cellular neuroscience · 2014Article
- Movement dependence and layer specificity of entorhinal phase precession in two-dimensional environments.PloS one · 2014Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
In active networks, excitatory and inhibitory synaptic inputs generate membrane voltage fluctuations that drive spike activity in a probabilistic manner. Despite this, some cells in vivo show a strong propensity to precisely lock to the local field potential and maintain a specific spike-phase relationship relative to other cells. In recordings from rat medial entorhinal cortical stellate cells, we measured spike phase-locking in response to sinusoidal "test" inputs in the presence of different forms of background membrane voltage fluctuations, generated via dynamic clamp. We find that stellate cells show strong and robust spike phase-locking to theta (4-12 Hz) inputs. This response occurs under a wide variety of background membrane voltage fluctuation conditions that include a substantial increase in overall membrane conductance. Furthermore, the IH current present in stellate cells is critical to the enhanced spike phase-locking response at theta. Finally, we show that correlations between inhibitory and excitatory conductance fluctuations, which can arise through feedback and feedforward inhibition, can substantially enhance the spike phase-locking response. The enhancement in locking is a result of a selective reduction in the size of low-frequency membrane voltage fluctuations due to cancellation of inhibitory and excitatory current fluctuations with correlations. Hence, our results demonstrate that stellate cells have a strong preference for spike phase-locking to theta band inputs and that the absolute magnitude of locking to theta can be modulated by the properties of background membrane voltage fluctuations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.